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ENZYME entry: EC 2.7.3.9

Accepted Name
phosphoenolpyruvate--protein phosphotransferase.
Alternative Name(s)
enzyme I of the phosphotransferase system.
phosphoenolpyruvate--protein phosphatase.
phosphoenolpyruvate sugar phosphotransferase enzyme I.
phosphopyruvate--protein factor phosphotransferase.
phosphopyruvate--protein phosphotransferase.
sugar--PEP phosphotransferase enzyme I.
Reaction catalysed
L-histidyl-[protein] + phosphoenolpyruvate <=> N(pros)-phospho-L-histidyl-[protein] + pyruvate
Comment(s)
  • Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport.
  • A similar reaction where the protein is the enzyme EC 2.7.9.2 is part of the mechanism of that enzyme.
Cross-references
BRENDA2.7.3.9
EC2PDB2.7.3.9
ExplorEnz2.7.3.9
PRIAM enzyme-specific profiles2.7.3.9
KEGG Ligand Database for Enzyme Nomenclature2.7.3.9
IUBMB Enzyme Nomenclature2.7.3.9
IntEnz2.7.3.9
MEDLINEFind literature relating to 2.7.3.9
MetaCyc2.7.3.9
Rhea expert-curated reactions2.7.3.9
UniProtKB/Swiss-Prot
P37177, PT1P_ECOLI;  P37178, PT1P_SALTY;  Q9K8D3, PT1_ALKHC;  
O83018, PT1_BACSI;  P08838, PT1_BACSU;  O51508, PT1_BORBU;  
Q9WXI6, PT1_BUCAI;  Q8KA50, PT1_BUCAP;  Q89B04, PT1_BUCBP;  
Q9PK57, PT1_CHLMU;  Q9Z9E3, PT1_CHLPN;  O84340, PT1_CHLTR;  
P23536, PT1_CUPNH;  P08839, PT1_ECOLI;  P23530, PT1_ENTFA;  
P42014, PT1_GEOSE;  P43922, PT1_HAEIN;  D4GYE2, PT1_HALVD;  
Q9CJ82, PT1_LACLA;  Q9ZAD8, PT1_LACLC;  O07126, PT1_LATSK;  
Q92D19, PT1_LISIN;  O31149, PT1_LISMO;  Q84F83, PT1_LYSSH;  
P45617, PT1_MYCCT;  P47668, PT1_MYCGE;  P75168, PT1_MYCPN;  
O69251, PT1_PRIMG;  P0A250, PT1_SALTI;  P0A249, PT1_SALTY;  
Q5HH01, PT1_STAAC;  Q931U2, PT1_STAAM;  Q99V14, PT1_STAAN;  
Q6GI01, PT1_STAAR;  Q6GAD0, PT1_STAAS;  P51183, PT1_STAAU;  
Q8NX83, PT1_STAAW;  P23533, PT1_STACT;  Q5HQ85, PT1_STAEQ;  
Q8CT19, PT1_STAES;  Q9KZP1, PT1_STRCO;  Q9WXK9, PT1_STREI;  
P45595, PT1_STRMU;  P30299, PT1_STRSL;  P23388, PTFAX_RHOCA;  
P45597, PTFAX_XANCP;  P77439, PTFX1_ECOLI;  P32670, PTFX2_ECOLI;  
Q8XBQ8, PTFX_ECO57;  Q8FFD8, PTFX_ECOL6;  Q83QP3, PTFX_SHIFL;  

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