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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.7.4.21

Accepted Name
Inositol-hexakisphosphate kinase.
Alternative Name(s)
ATP:1D-myo-inositol-hexakisphosphate phosphotransferase.
IP6K.
Reaction catalysed
  • ATP + 1D-myo-inositol hexakisphosphate <=> ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
  • ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate <=> ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Comment(s)
  • Three mammalian isoforms are known to exist.
  • Formerly EC 2.7.1.152.
Cross-references
BRENDA2.7.4.21
EC2PDB2.7.4.21
ExplorEnz2.7.4.21
PRIAM enzyme-specific profiles2.7.4.21
KEGG Ligand Database for Enzyme Nomenclature2.7.4.21
IUBMB Enzyme Nomenclature2.7.4.21
IntEnz2.7.4.21
MEDLINEFind literature relating to 2.7.4.21
MetaCyc2.7.4.21
UniProtKB/Swiss-Prot
Q92551, IP6K1_HUMAN;  Q6PD10, IP6K1_MOUSE;  Q9ESM0, IP6K1_RAT;  
Q9UHH9, IP6K2_HUMAN;  Q80V72, IP6K2_MOUSE;  Q95221, IP6K2_RABIT;  
Q9R0U1, IP6K2_RAT;  Q96PC2, IP6K3_HUMAN;  Q8BWD2, IP6K3_MOUSE;  
Q12494, KCS1_YEAST;  F4J8C6, VIP1L_ARATH;  A7Z050, VIP1_BOVIN;  
P91309, VIP1_CAEEL;  Q9VR59, VIP1_DROME;  Q6PFW1, VIP1_HUMAN;  
A2ARP1, VIP1_MOUSE;  Q5RDF1, VIP1_PONAB;  P0C644, VIP1_RAT;  
O74429, VIP1_SCHPO;  Q06685, VIP1_YEAST;  Q84WW3, VIP2L_ARATH;  
O43314, VIP2_HUMAN;  Q6ZQB6, VIP2_MOUSE;  Q5REW0, VIP2_PONAB;  
Q5XHF8, VIP2_XENLA;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-