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ENZYME

ENZYME entry: EC 2.7.4.24

PURL: https://purl.expasy.org/enzyme/EC/2.7.4.24
Accepted Name
diphosphoinositol-pentakisphosphate 1-kinase
Alternative Name(s)
diphosphoinositol-pentakisphosphate 1/3-kinase
diphosphoinositol pentakisphosphate kinase
diphosphoinositol-pentakisphosphate kinase
PP-InsP5 kinase
PP-IP5 kinase
Reaction catalysed
  • 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
  • 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
Comment(s)
  • This enzyme is activated by osmotic shock.
  • Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates.
  • The enzyme specifically phosphorylates the 1-position of the substrates.
  • Formerly EC 2.7.1.155.
Cross-references
BRENDA2.7.4.24
EC2PDB2.7.4.24
ExplorEnz2.7.4.24
KEGG Ligand Database for Enzyme Nomenclature2.7.4.24
IUBMB Enzyme Nomenclature2.7.4.24
MEDLINEFind literature relating to 2.7.4.24
MetaCyc2.7.4.24
Rhea expert-curated reactions2.7.4.24
UniProtKB/Swiss-Prot
F4J8C6, VIP1L_ARATHA7Z050, VIP1_BOVINP91309, VIP1_CAEEL
Q9VR59, VIP1_DROMEQ6PFW1, VIP1_HUMANA2ARP1, VIP1_MOUSE
Q5RDF1, VIP1_PONABP0C644, VIP1_RATO74429, VIP1_SCHPO
Q06685, VIP1_YEASTQ84WW3, VIP2L_ARATHO43314, VIP2_HUMAN
Q6ZQB6, VIP2_MOUSEQ5REW0, VIP2_PONABQ5XHF8, VIP2_XENLA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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