Home  |  Contact

ENZYME entry: EC 2.7.4.24

Accepted Name
diphosphoinositol-pentakisphosphate 1-kinase.
Alternative Name(s)
diphosphoinositol-pentakisphosphate 1/3-kinase.
diphosphoinositol pentakisphosphate kinase.
diphosphoinositol-pentakisphosphate kinase.
PP-InsP5 kinase.
PP-IP5 kinase.
Reaction catalysed
  • 1D-myo-inositol hexakisphosphate + ATP <=> 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
  • 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP
Comment(s)
  • This enzyme is activated by osmotic shock.
  • Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates.
  • The enzyme specifically phosphorylates the 1-position of the substrates.
  • Formerly EC 2.7.1.155.
Cross-references
BRENDA2.7.4.24
EC2PDB2.7.4.24
ExplorEnz2.7.4.24
PRIAM enzyme-specific profiles2.7.4.24
KEGG Ligand Database for Enzyme Nomenclature2.7.4.24
IUBMB Enzyme Nomenclature2.7.4.24
IntEnz2.7.4.24
MEDLINEFind literature relating to 2.7.4.24
MetaCyc2.7.4.24
Rhea expert-curated reactions2.7.4.24
UniProtKB/Swiss-Prot
F4J8C6, VIP1L_ARATH;  A7Z050, VIP1_BOVIN;  P91309, VIP1_CAEEL;  
Q9VR59, VIP1_DROME;  Q6PFW1, VIP1_HUMAN;  A2ARP1, VIP1_MOUSE;  
Q5RDF1, VIP1_PONAB;  P0C644, VIP1_RAT;  O74429, VIP1_SCHPO;  
Q06685, VIP1_YEAST;  Q84WW3, VIP2L_ARATH;  O43314, VIP2_HUMAN;  
Q6ZQB6, VIP2_MOUSE;  Q5REW0, VIP2_PONAB;  Q5XHF8, VIP2_XENLA;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-