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ENZYME entry: EC 2.7.7.100

Accepted Name
SAMP-activating enzyme.
Alternative Name(s)
SAMP-activating enzyme E1.
Reaction catalysed
ATP + [SAMP]-Gly-Gly <=> diphosphate + [SAMP]-Gly-Gly-AMP
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme catalyzes the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea, by catalyzing the ATP-dependent formation of a SAMP adenylate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage.
  • The product of this activity can accept a sulfur atom to form a thiocarboxylate moiety that acts as a sulfur carrier involved in thiolation of tRNA and other metabolites such as molybdopterin.
  • Alternatively, the enzyme can also catalyze the transfer of SAMP from its activated form to an internal cysteine residue, leading to a process termed SAMPylation (see EC 6.2.1.55).
Cross-references
BRENDA2.7.7.100
EC2PDB2.7.7.100
ExplorEnz2.7.7.100
PRIAM enzyme-specific profiles2.7.7.100
KEGG Ligand Database for Enzyme Nomenclature2.7.7.100
IUBMB Enzyme Nomenclature2.7.7.100
IntEnz2.7.7.100
MEDLINEFind literature relating to 2.7.7.100
MetaCyc2.7.7.100
Rhea expert-curated reactions2.7.7.100

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