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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
SAMP-activating enzyme.
Alternative Name(s)
SAMP-activating enzyme E1.
Reaction catalysed
ATP + [SAMP]-Gly-Gly <=> diphosphate + [SAMP]-Gly-Gly-AMP
  • The enzyme catalyzes the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea, by catalyzing the ATP-dependent formation of a SAMP adenylate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage.
  • The product of this activity can accept a sulfur atom to form a thiocarboxylate moiety that acts as a sulfur carrier involved in thiolation of tRNA and other metabolites such as molybdopterin.
  • Alternatively, the enzyme can also catalyze the transfer of SAMP from its activated form to an internal cysteine residue, leading to a process termed SAMPylation (see EC
PRIAM enzyme-specific profiles2.7.7.100
KEGG Ligand Database for Enzyme Nomenclature2.7.7.100
IUBMB Enzyme Nomenclature2.7.7.100
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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