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ENZYME entry: EC

Accepted Name
SAMP-activating enzyme
Alternative Name(s)
SAMP-activating enzyme E1
Reaction catalysed
[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate
  • The enzyme catalyzes the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea, by catalyzing the ATP-dependent formation of a SAMP adenylate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage.
  • The product of this activity can accept a sulfur atom to form a thiocarboxylate moiety that acts as a sulfur carrier involved in thiolation of tRNA and other metabolites such as molybdopterin.
  • Alternatively, the enzyme can also catalyze the transfer of SAMP from its activated form to an internal cysteine residue, leading to a process termed SAMPylation (see EC
PRIAM enzyme-specific profiles2.7.7.100
KEGG Ligand Database for Enzyme Nomenclature2.7.7.100
IUBMB Enzyme Nomenclature2.7.7.100
MEDLINEFind literature relating to
Rhea expert-curated reactions2.7.7.100

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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