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ENZYME

ENZYME entry: EC 2.7.7.19

Accepted Name
polynucleotide adenylyltransferase
Alternative Name(s)
NTP polymerase
poly(A) polymerase
RNA adenylating enzyme
Reaction catalysed
ATP + RNA(n) <=> diphosphate + RNA(n)-3'-adenine ribonucleotide
Comment(s)
  • Also acts slowly with CTP.
  • Catalyzes template-independent extension of the 3'-end of a RNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group.
  • See also EC 2.7.7.6.
Cross-references
BRENDA2.7.7.19
EC2PDB2.7.7.19
ExplorEnz2.7.7.19
PRIAM enzyme-specific profiles2.7.7.19
KEGG Ligand Database for Enzyme Nomenclature2.7.7.19
IUBMB Enzyme Nomenclature2.7.7.19
IntEnz2.7.7.19
MEDLINEFind literature relating to 2.7.7.19
MetaCyc2.7.7.19
Rhea expert-curated reactions2.7.7.19
UniProtKB/Swiss-Prot
O74326, CID11_SCHPOO74518, CID12_SCHPOQ9UT49, CID13_SCHPO
Q9UTN3, CID14_SCHPOO13833, CID1_SCHPOQ9VD44, GLD2A_DROME
Q641A1, GLD2A_XENLAQ9VYS4, GLD2B_DROMEQ6DFA8, GLD2B_XENLA
Q2HJ44, GLD2_BOVINO17087, GLD2_CAEELQ503I9, GLD2_DANRE
Q6PIY7, GLD2_HUMANQ91YI6, GLD2_MOUSEQ5U315, GLD2_RAT
Q0VFA3, GLD2_XENTRG5EFL0, GLD4_CAEELQ65159, PAP1_ASFB7
P0C9D5, PAP1_ASFK5P0C9D2, PAP1_ASFM2P0C9D3, PAP1_ASFP4
P0C9D4, PAP1_ASFWAQ8V2W4, PAP1_CAMPMQ8QQ67, PAP1_CAMPS
Q6VZL8, PAP1_CNPVQ070J7, PAP1_CPRVZQ8QMZ9, PAP1_CWPXB
Q80E12, PAP1_CWPXGQ08FW1, PAP1_DPV83Q08FE1, PAP1_DPV84
Q8JLG4, PAP1_ECTVMP0DTA7, PAP1_FOWPNP0DTA8, PAP1_FOWPV
Q0GP30, PAP1_HSPVQ91MX5, PAP1_LSDVNQ98199, PAP1_MCV1
Q5UQS6, PAP1_MIMIVA0A7H0DN36, PAP1_MONPVQ9Q8R9, PAP1_MYXVL
Q2F8F7, PAP1_ORFN2Q6RZP5, PAP1_RABPUQ9Q944, PAP1_RFVKA
Q8V3R4, PAP1_SWPV1O57184, PAP1_VACCAP21079, PAP1_VACCC
Q9JFD9, PAP1_VACCTP23371, PAP1_VACCWP0DOM1, PAP1_VAR67
P0DOM2, PAP1_VARVQ9DHT0, PAP1_YLDVQ6TUY0, PAP1_YMTV5
P53632, PAP2_YEASTQ9UW26, PAPA_CANALO46102, PAPD1_DROME
Q9NVV4, PAPD1_HUMANQ9D0D3, PAPD1_MOUSEQ8NDF8, PAPD5_HUMAN
Q68ED3, PAPD5_MOUSEQ5XG87, PAPD7_HUMANQ6PB75, PAPD7_MOUSE
P51004, PAPO1_XENLAP51005, PAPO2_XENLAP51006, PAPO3_XENLA
P25500, PAPOA_BOVINP51003, PAPOA_HUMANQ61183, PAPOA_MOUSE
Q9NRJ5, PAPOB_HUMANQ9WVP6, PAPOB_MOUSEQ9BWT3, PAPOG_HUMAN
Q6PCL9, PAPOG_MOUSEQ9LMT2, PAPS1_ARATHO82312, PAPS2_ARATH
Q56XM9, PAPS3_ARATHQ8VYW1, PAPS4_ARATHO42617, PAP_CANAL
Q54J73, PAP_DICDIQ51D88, PAP_ENTH1Q10295, PAP_SCHPO
P29468, PAP_YEASTP0ABF3, PCNB_ECO57P0ABF2, PCNB_ECOL6
P0ABF1, PCNB_ECOLIP44439, PCNB_HAEINQ8Z9C3, PCNB_SALTI
Q8ZRQ8, PCNB_SALTYQ86924, POLN_AURAVP87515, POLN_BFV
Q5XXP4, POLN_CHIK3Q8JUX6, POLN_CHIKSQ306W6, POLN_EEEV1
Q306W8, POLN_EEEV8Q4QXJ8, POLN_EEEVFP36327, POLN_EEVV3
Q8V294, POLN_EEVVCQ9WJC7, POLN_EEVVMP36328, POLN_EEVVP
P27282, POLN_EEVVTQ5Y389, POLN_GETVQ8QZ73, POLN_MAYAB
P03318, POLN_MIDDVP13886, POLN_ONNVGO90370, POLN_ONNVI
O90368, POLN_ONNVSP13887, POLN_RRVNP13888, POLN_RRVT
Q9JGL0, POLN_SAGVP08411, POLN_SFVP27283, POLN_SINDO
P03317, POLN_SINDVQ8QL53, POLN_SLDVQ8JJX1, POLN_SPDV
P13896, POLN_WEEVD2HS90, STPAP_AILMEQ1JPD6, STPAP_BOVIN
Q4KMD7, STPAP_DANREQ9H6E5, STPAP_HUMANQ8R3F9, STPAP_MOUSE
Q3MHT4, STPAP_RATA9JTS5, STPAP_XENTRQ96IP4, TET5A_HUMAN
D3Z5S8, TET5A_MOUSEQ29RH2, TET5B_BOVINQ96A09, TET5B_HUMAN
Q8C152, TET5B_MOUSEB0BNK8, TET5B_RATF7E7M3, TET5B_XENTR
Q5ZL95, TET5C_CHICKQ7ZUP1, TET5C_DANREQ5VWP2, TET5C_HUMAN
Q4R8X4, TET5C_MACFAQ5SSF7, TET5C_MOUSEQ5XIV0, TET5C_RAT
Q8NEK8, TET5D_HUMANQ7KVS9, TRF41_DROMEQ9HFW3, TRF5_ASHGO
P48561, TRF5_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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