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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.7.7.19

Accepted Name
Polynucleotide adenylyltransferase.
Alternative Name(s)
NTP polymerase.
Poly(A) polymerase.
RNA adenylating enzyme.
Reaction catalysed
ATP + RNA(n) <=> diphosphate + RNA(n+1)
Comment(s)
  • Also acts slowly with CTP.
  • Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group.
  • See also EC 2.7.7.6.
Cross-references
BRENDA2.7.7.19
EC2PDB2.7.7.19
ExplorEnz2.7.7.19
PRIAM enzyme-specific profiles2.7.7.19
KEGG Ligand Database for Enzyme Nomenclature2.7.7.19
IUBMB Enzyme Nomenclature2.7.7.19
IntEnz2.7.7.19
MEDLINEFind literature relating to 2.7.7.19
MetaCyc2.7.7.19
UniProtKB/Swiss-Prot
O74326, CID11_SCHPO;  O74518, CID12_SCHPO;  Q9UT49, CID13_SCHPO;  
Q9UTN3, CID14_SCHPO;  O13833, CID1_SCHPO;  Q9VD44, GLD2A_DROME;  
Q641A1, GLD2A_XENLA;  Q9VYS4, GLD2B_DROME;  Q6DFA8, GLD2B_XENLA;  
Q2HJ44, GLD2_BOVIN;  O17087, GLD2_CAEEL;  Q503I9, GLD2_DANRE;  
Q6PIY7, GLD2_HUMAN;  Q91YI6, GLD2_MOUSE;  Q5U315, GLD2_RAT;  
Q0VFA3, GLD2_XENTR;  G5EFL0, GLD4_CAEEL;  Q65159, PAP1_ASFB7;  
P0C9D5, PAP1_ASFK5;  P0C9D2, PAP1_ASFM2;  P0C9D3, PAP1_ASFP4;  
P0C9D4, PAP1_ASFWA;  Q8V2W4, PAP1_CAMPM;  Q8QQ67, PAP1_CAMPS;  
Q6VZL8, PAP1_CNPV;  Q070J7, PAP1_CPRVZ;  Q8QMZ9, PAP1_CWPXB;  
Q80E12, PAP1_CWPXG;  Q08FW1, PAP1_DPV83;  Q08FE1, PAP1_DPV84;  
Q8JLG4, PAP1_ECTVM;  Q9J5B8, PAP1_FOWPN;  Q0GP30, PAP1_HSPV;  
Q91MX5, PAP1_LSDVN;  Q98199, PAP1_MCV1;  Q5UQS6, PAP1_MIMIV;  
Q9Q8R9, PAP1_MYXVL;  Q2F8F7, PAP1_ORFN2;  Q6RZP5, PAP1_RABPU;  
Q9Q944, PAP1_RFVKA;  Q8V3R4, PAP1_SWPV1;  O57184, PAP1_VACCA;  
P21079, PAP1_VACCC;  Q9JFD9, PAP1_VACCT;  P23371, PAP1_VACCW;  
P33809, PAP1_VAR67;  Q9DHT0, PAP1_YLDV;  Q6TUY0, PAP1_YMTV5;  
P53632, PAP2_YEAST;  Q9UW26, PAPA_CANAL;  O46102, PAPD1_DROME;  
Q9NVV4, PAPD1_HUMAN;  Q9D0D3, PAPD1_MOUSE;  Q8NDF8, PAPD5_HUMAN;  
Q68ED3, PAPD5_MOUSE;  Q5XG87, PAPD7_HUMAN;  Q6PB75, PAPD7_MOUSE;  
P51004, PAPO1_XENLA;  P51005, PAPO2_XENLA;  P51006, PAPO3_XENLA;  
P25500, PAPOA_BOVIN;  P51003, PAPOA_HUMAN;  Q61183, PAPOA_MOUSE;  
Q9NRJ5, PAPOB_HUMAN;  Q9WVP6, PAPOB_MOUSE;  Q9BWT3, PAPOG_HUMAN;  
Q6PCL9, PAPOG_MOUSE;  Q9LMT2, PAPS1_ARATH;  O82312, PAPS2_ARATH;  
Q56XM9, PAPS3_ARATH;  Q8VYW1, PAPS4_ARATH;  O42617, PAP_CANAL;  
Q54J73, PAP_DICDI;  Q51D88, PAP_ENTHI;  Q10295, PAP_SCHPO;  
P29468, PAP_YEAST;  P0ABF3, PCNB_ECO57;  P0ABF2, PCNB_ECOL6;  
P0ABF1, PCNB_ECOLI;  P44439, PCNB_HAEIN;  Q8Z9C3, PCNB_SALTI;  
Q8ZRQ8, PCNB_SALTY;  D2HS90, STPAP_AILME;  Q1JPD6, STPAP_BOVIN;  
Q4KMD7, STPAP_DANRE;  Q9H6E5, STPAP_HUMAN;  Q8R3F9, STPAP_MOUSE;  
Q3MHT4, STPAP_RAT;  A9JTS5, STPAP_XENTR;  Q5ZL95, TET5C_CHICK;  
Q7ZUP1, TET5C_DANRE;  Q5VWP2, TET5C_HUMAN;  Q4R8X4, TET5C_MACFA;  
Q5SSF7, TET5C_MOUSE;  Q5XIV0, TET5C_RAT;  Q8NEK8, TET5D_HUMAN;  
Q7KVS9, TRF41_DROME;  Q9HFW3, TRF5_ASHGO;  P48561, TRF5_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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