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ENZYME

ENZYME entry: EC 2.7.7.46

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.46
Accepted Name
gentamicin 2''-nucleotidyltransferase
Alternative Name(s)
2''-aminoglycoside nucleotidyltransferase
Reaction catalysed
nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin
Comment(s)
  • ATP, dATP, CTP, ITP and GTP can act as donors.
  • Kanamycin, tobramycin and sisomicin can also act as acceptors.
  • The nucleotidyl residue is transferred to the 2-hydroxy group of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
Cross-references
BRENDA2.7.7.46
EC2PDB2.7.7.46
ExplorEnz2.7.7.46
KEGG Ligand Database for Enzyme Nomenclature2.7.7.46
IUBMB Enzyme Nomenclature2.7.7.46
MEDLINEFind literature relating to 2.7.7.46
MetaCyc2.7.7.46
Rhea expert-curated reactions2.7.7.46
UniProtKB/Swiss-Prot
P0AE05, AADB1_KLEPNP29806, AADB2_KLEPNP0AE04, AADB_ECOLX

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