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ENZYME

ENZYME entry: EC 2.7.7.49

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.49
Accepted Name
RNA-directed DNA polymerase
Alternative Name(s)
DNA nucleotidyltransferase (RNA-directed)
reverse transcriptase
revertase
Reaction catalysed
DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
Comment(s)
  • Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a RNA or DNA primer.
  • DNA can also serve as template.
  • See also EC 2.7.7.7.
Cross-references
BRENDA2.7.7.49
EC2PDB2.7.7.49
ExplorEnz2.7.7.49
KEGG Ligand Database for Enzyme Nomenclature2.7.7.49
IUBMB Enzyme Nomenclature2.7.7.49
MEDLINEFind literature relating to 2.7.7.49
MetaCyc2.7.7.49
Rhea expert-curated reactions2.7.7.49
UniProtKB/Swiss-Prot
O75417, DPOLQ_HUMANQ8CGS6, DPOLQ_MOUSEQ64898, DPOL_ASHV
P03162, DPOL_DHBV1P0C691, DPOL_DHBV3Q66403, DPOL_DHBVQ
P03161, DPOL_GSHVP03158, DPOL_HBVA2P03159, DPOL_HBVA3
P17100, DPOL_HBVA4Q02314, DPOL_HBVA5Q91C36, DPOL_HBVA6
O91533, DPOL_HBVA7Q4R1S7, DPOL_HBVA8Q4R1R9, DPOL_HBVA9
P17394, DPOL_HBVB1P17393, DPOL_HBVB2Q9QAB8, DPOL_HBVB3
P17395, DPOL_HBVB4Q9PX62, DPOL_HBVB5Q67925, DPOL_HBVB6
Q9QBF1, DPOL_HBVB7P0C676, DPOL_HBVB8Q9E6S5, DPOL_HBVC0
P0C688, DPOL_HBVC1Q9YZR5, DPOL_HBVC2P12933, DPOL_HBVC3
P31870, DPOL_HBVC4P03157, DPOL_HBVC5Q913A7, DPOL_HBVC7
Q81165, DPOL_HBVC8P0C690, DPOL_HBVC9Q69028, DPOL_HBVCJ
P12900, DPOL_HBVCPP03155, DPOL_HBVD1P24024, DPOL_HBVD2
P03156, DPOL_HBVD3Q9QMI1, DPOL_HBVD4P0C679, DPOL_HBVD5
Q67878, DPOL_HBVD6O56655, DPOL_HBVD7Q69602, DPOL_HBVE1
Q80IU7, DPOL_HBVE2Q9QAW8, DPOL_HBVE3Q80IU4, DPOL_HBVE4
Q05486, DPOL_HBVF1Q8JMY4, DPOL_HBVF2Q99HS4, DPOL_HBVF3
Q99HR5, DPOL_HBVF4Q69605, DPOL_HBVF6Q8QZQ2, DPOL_HBVG2
Q9IBI4, DPOL_HBVG3P87744, DPOL_HBVGBQ9YPV8, DPOL_HBVGO
Q8JMY7, DPOL_HBVH1Q8JN08, DPOL_HBVH2Q8JMZ7, DPOL_HBVH3
Q9J5S2, DPOL_HBVORP13846, DPOL_HHBVP17192, DPOL_HPBDB
P30028, DPOL_HPBDCP17193, DPOL_HPBDWP03160, DPOL_WHV1
P06275, DPOL_WHV2P12899, DPOL_WHV3P12898, DPOL_WHV4
P17396, DPOL_WHV5P11292, DPOL_WHV6O71304, DPOL_WMHBV
P08548, LIN1_NYCCOO00370, LORF2_HUMANP11369, LORF2_MOUSE
P0A3U0, LTRA_LACLCP0A3U1, LTRA_LACLMP63132, PO113_HUMAN
Q03277, PO11_BRACOQ03269, PO11_NASVIQ03276, PO11_POPJA
Q03270, PO12_NASVIQ03271, PO13_NASVIQ03272, PO14_NASVI
Q03279, PO21_BRACOQ03278, PO21_NASVIQ03273, PO21_POPJA
Q03274, PO22_POPJAQ05118, PO23_POPJAQ03275, PO24_POPJA
P10266, POK10_HUMANQ9UQG0, POK11_HUMANQ9QC07, POK18_HUMAN
Q9WJR5, POK19_HUMANP63136, POK25_HUMANQ9BXR3, POK6_HUMAN
P63135, POK7_HUMANP63133, POK8_HUMANP63128, POK9_HUMAN
P10399, POL1_CHICKP10400, POL1_MOUSEP20825, POL2_DROME
P04323, POL3_DROMEP10394, POL4_DROMEQ8I7P9, POL5_DROME
Q91DM0, POLG_PVCV1Q6XKE6, POLG_PVCV2Q94HW2, POLR1_ARATH
Q9ZT94, POLR2_ARATHP16423, POLR_DROMEP10978, POLX_TOBAC
P10401, POLY_DROMEQ7SQ98, POL_ALVQ04095, POL_ALVA
P03360, POL_AVIREP10272, POL_BAEVMP19560, POL_BIV29
P25059, POL_BLVAUP03361, POL_BLVJP33459, POL_CAEVC
P03555, POL_CAMVCP03556, POL_CAMVDQ02964, POL_CAMVE
Q00962, POL_CAMVNP03554, POL_CAMVSP05400, POL_CERV
P19199, POL_COYMVQ89703, POL_CSVMVQ7TD08, POL_CYLCV
P11204, POL_EIAV9P32542, POL_EIAVCP03371, POL_EIAVY
P31792, POL_FENV1O93209, POL_FFVP16088, POL_FIVPE
P19028, POL_FIVSDP31822, POL_FIVT2P10273, POL_FLV
P09523, POL_FMVDP14350, POL_FOAMVP21414, POL_GALV
P03362, POL_HTL1AP14078, POL_HTL1CP0C211, POL_HTL1L
Q0R5R2, POL_HTL32Q4U0X6, POL_HTL3PP03363, POL_HTLV2
O93215, POL_HV190O12158, POL_HV192O89290, POL_HV193
Q9QBY3, POL_HV196Q9QBZ9, POL_HV197O41798, POL_HV19N
P03369, POL_HV1A2Q77373, POL_HV1ANP03366, POL_HV1B1
P04587, POL_HV1B5Q73368, POL_HV1B9P03367, POL_HV1BR
P04589, POL_HV1ELQ75002, POL_HV1ETP04585, POL_HV1H2
P20875, POL_HV1JRP0C6F2, POL_HV1LWQ9QBZ1, POL_HV1M2
P04588, POL_HV1MAP05961, POL_HV1MNQ9QBZ5, POL_HV1MP
Q79666, POL_HV1MVP12497, POL_HV1N5P18802, POL_HV1ND
P20892, POL_HV1OYP05959, POL_HV1RHQ9WC54, POL_HV1S2
Q9WC63, POL_HV1S9O89940, POL_HV1SEP24740, POL_HV1U4
Q9Q720, POL_HV1V9Q9QSR3, POL_HV1VIP35963, POL_HV1Y2
Q9IDV9, POL_HV1YBO91080, POL_HV1YFP12499, POL_HV1Z2
P18096, POL_HV2BEP24107, POL_HV2CAP17757, POL_HV2D1
P15833, POL_HV2D2Q89928, POL_HV2EHP18042, POL_HV2G1
Q74120, POL_HV2KRP05962, POL_HV2NZP04584, POL_HV2RO
P12451, POL_HV2SBP20876, POL_HV2STQ76634, POL_HV2UC
P04026, POL_IPHAP11368, POL_IPMAP12894, POL_IPMAI
Q82851, POL_JEMBRP31623, POL_JSRVQ9TTC1, POL_KORV
P03356, POL_MLVAVQ7SVK7, POL_MLVBMP08361, POL_MLVCB
P26810, POL_MLVF5P26809, POL_MLVFFP26808, POL_MLVFP
P03355, POL_MLVMSP11227, POL_MLVRDP31795, POL_MLVRK
P03365, POL_MMTVBP11283, POL_MMTVCP07572, POL_MPMV
P16901, POL_OMVVSP03354, POL_RSVPO92956, POL_RSVSB
P27502, POL_RTBVPP23074, POL_SFV1P27401, POL_SFV3L
Q87040, POL_SFVCPP17283, POL_SIVCZQ1A249, POL_SIVEK
Q02836, POL_SIVG1P22382, POL_SIVGBP05896, POL_SIVM1
P05897, POL_SIVM2Q1A267, POL_SIVMBP12502, POL_SIVS4
P19505, POL_SIVSPQ8AII1, POL_SIVTNP27973, POL_SIVV1
P27980, POL_SIVVGP05895, POL_SIVVTP03364, POL_SMRVH
P15629, POL_SOCMVP04025, POL_SRV1P51517, POL_SRV2
P03370, POL_VILVP23426, POL_VILV1P23427, POL_VILV2
P35956, POL_VILVKO92815, POL_WDSVP03359, POL_WMSV
Q2F7J3, POL_XMRV3Q2F7J0, POL_XMRV4A1Z651, POL_XMRV6
P19593, RDPO_TETOBP23072, RT162_MYXXAP71276, RT48_ECOLX
P23071, RT65_MYXXAP21325, RT67_ECOLXP0DV89, RT72_SALH5
P0DV86, RT73_ECOLXQ46666, RT78_ECOLXQ47526, RT83_ECOLX
P23070, RT86_ECOLXP0DV59, RT8_ECOLXP0DV94, RT95_VIBCE
Q95SX7, RTBS_DROMEP21329, RTJK_DROFUP21328, RTJK_DROME
P15594, RTP2_TRYBGQ9NBX4, RTXE_DROMEQ94818, TE80_TETTH
Q94819, TE95_TETTHQ9SPU7, TERT_ARATHQ27ID4, TERT_BOVIN
Q6A548, TERT_CANLFO00939, TERT_EUPAEO14746, TERT_HUMAN
O70372, TERT_MOUSEQ1PS67, TERT_ORYLAQ8LKW0, TERT_ORYSJ
O76332, TERT_OXYTRQ673L6, TERT_RATO13339, TERT_SCHPO
Q4KTA7, TERT_TAKRUO77448, TERT_TETTSQ06163, TERT_YEAST
Q01910, TF107_SCHPMA0AAN2H6E2, TF210_SCHPOQ9UR07, TF211_SCHPO
P0CT41, TF212_SCHPOA0AAN2H8A8, TF213_SCHPOP0CT34, TF21_SCHPO
P0CT35, TF22_SCHPOP0CT36, TF23_SCHPOP0CT37, TF24_SCHPO
P0CT38, TF25_SCHPOP0CT39, TF26_SCHPOP0CT42, TF27_SCHPO
P0CT43, TF28_SCHPOP0CT40, TF29_SCHPOQ07163, TY1AB_YEASX
O13527, YA11B_YEASTQ12490, YB11B_YEASTQ12193, YB12B_YEAST
Q12491, YB21B_YEASTP25384, YC21B_YEASTQ03855, YD11B_YEAST
Q99231, YD12B_YEASTQ07793, YD13B_YEASTP0C2I2, YD14B_YEAST
P0C2I3, YD15B_YEASTQ12472, YD21B_YEASTQ03494, YD22B_YEAST
Q07791, YD23B_YEASTQ03612, YE11B_YEASTQ03619, YE12B_YEAST
P0CX63, YF21B_YEASTQ12141, YG11B_YEASTQ12269, YG12B_YEAST
Q12316, YG13B_YEASTQ12337, YG21B_YEASTP0CX64, YG22B_YEAST
Q99315, YG31B_YEASTO13535, YH11B_YEASTP0C2J7, YH41B_YEAST
Q7LHG5, YI31B_YEASTP47098, YJ11B_YEASTP47100, YJ12B_YEAST
P47024, YJ41B_YEASTQ12088, YL11B_YEASTP0C2I5, YL12B_YEAST
P0C2I6, YL13B_YEASTP0C2I7, YL14B_YEASTP0C2J3, YL21B_YEAST
P0C2J5, YL22B_YEASTQ04711, YM11B_YEASTQ03434, YM12B_YEAST
Q04214, YM13B_YEASTQ04670, YM14B_YEASTQ12112, YN11B_YEAST
Q99337, YN12B_YEASTQ12273, YO11B_YEASTQ92393, YO12B_YEAST
Q12113, YO21B_YEASTQ12501, YO22B_YEASTQ12414, YP11B_YEAST
P0C2I9, YP12B_YEASTP0C2J0, YP13B_YEASTP0C2J1, YP14B_YEAST
A0A0B7P3V8, YP41B_YEAST

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-