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ENZYME

ENZYME entry: EC 2.7.7.60

Accepted Name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Alternative Name(s)
4-diphosphocytidyl-2-C-methyl-D-erythritol synthase
MCT
MEP cytidylyltransferase
Reaction catalysed
2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate
Comment(s)
  • ATP or UTP can replace CTP, but both are less effective.
  • GTP and TTP are not substrates.
  • Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
Cross-references
BRENDA2.7.7.60
EC2PDB2.7.7.60
ExplorEnz2.7.7.60
PRIAM enzyme-specific profiles2.7.7.60
KEGG Ligand Database for Enzyme Nomenclature2.7.7.60
IUBMB Enzyme Nomenclature2.7.7.60
IntEnz2.7.7.60
MEDLINEFind literature relating to 2.7.7.60
MetaCyc2.7.7.60
Rhea expert-curated reactions2.7.7.60
UniProtKB/Swiss-Prot
Q8UFF4, ISPDF_AGRFCB9JF01, ISPDF_AGRRKQ21YT7, ISPDF_ALBFT
A8ER37, ISPDF_ALIB4B9JW91, ISPDF_ALLAMQ2IQG8, ISPDF_ANADE
A7HDA2, ISPDF_ANADFA8IBL6, ISPDF_AZOC5A1USA2, ISPDF_BARBK
Q6G3Z8, ISPDF_BARHEQ6G164, ISPDF_BARQUA9IS87, ISPDF_BART1
Q89LQ8, ISPDF_BRADUA5EIY9, ISPDF_BRASBA4YUQ7, ISPDF_BRASO
Q2YPW1, ISPDF_BRUA2A6X0N1, ISPDF_BRUA4Q57D18, ISPDF_BRUAB
Q8YHD8, ISPDF_BRUMEA5VQP4, ISPDF_BRUO2Q8G0H4, ISPDF_BRUSU
A7ZCQ2, ISPDF_CAMC1A7GZI1, ISPDF_CAMC5A0RN28, ISPDF_CAMFF
A7I1V2, ISPDF_CAMHCA8FNR8, ISPDF_CAMJ8A7H5V8, ISPDF_CAMJD
Q9PM68, ISPDF_CAMJEA1W1K9, ISPDF_CAMJJQ5HSI4, ISPDF_CAMJR
B9KEX3, ISPDF_CAMLRQ9A7I5, ISPDF_CAUVCB8GW85, ISPDF_CAUVN
Q11HV9, ISPDF_CHESBA5CTY4, ISPDF_CLAM3B1I0S9, ISPDF_DESAP
Q6ARN9, ISPDF_DESPSQ72C30, ISPDF_DESVHA1VDX6, ISPDF_DESVV
A8LKV5, ISPDF_DINSHQ2NAE1, ISPDF_ERYLHQ5FQD6, ISPDF_GLUOX
Q0BTD5, ISPDF_GRABCQ17WU1, ISPDF_HELAHQ7VFU3, ISPDF_HELHP
B6JL03, ISPDF_HELP2B5Z6H4, ISPDF_HELPGQ1CU78, ISPDF_HELPH
Q9ZM19, ISPDF_HELPJB2USR1, ISPDF_HELPSO25664, ISPDF_HELPY
Q0C0N0, ISPDF_HYPNAQ28Q60, ISPDF_JANSCQ1MR76, ISPDF_LAWIP
Q6ADI0, ISPDF_LEIXXQ2W4Q8, ISPDF_MAGSAQ0APQ6, ISPDF_MARMM
Q1QM99, ISPDF_NITHXA6Q2K0, ISPDF_NITSBQ3SSN8, ISPDF_NITWN
Q2G708, ISPDF_NOVADQ310X3, ISPDF_OLEA2A1B890, ISPDF_PARDP
A7HXV6, ISPDF_PARL1Q4FM31, ISPDF_PELUBB3PYS4, ISPDF_RHIE6
Q2K8V5, ISPDF_RHIECQ1MH21, ISPDF_RHIL3Q98MX9, ISPDF_RHILO
B5ZNB6, ISPDF_RHILWQ92Q90, ISPDF_RHIMEA5V2U9, ISPDF_RHIWR
Q08113, ISPDF_RHOCBQ2IW23, ISPDF_RHOP2Q07MZ2, ISPDF_RHOP5
Q6N6M5, ISPDF_RHOPAQ214R1, ISPDF_RHOPBQ137C3, ISPDF_RHOPS
B3QIL5, ISPDF_RHOPTQ2RTS1, ISPDF_RHORTQ5LRN5, ISPDF_RUEPO
Q1GGW9, ISPDF_RUESTA6U8F8, ISPDF_SINMWC4XSW4, ISPDF_SOLM1
Q1GTN0, ISPDF_SPHALQ30QG7, ISPDF_SULDNA6Q7M3, ISPDF_SULNB
O83525, ISPDF_TREPAQ83NK3, ISPDF_TROW8Q83MX3, ISPDF_TROWT
Q73G24, ISPDF_WOLPMQ7MQW9, ISPDF_WOLSUQ5GSM7, ISPDF_WOLTR
Q9RNZ1, ISPDF_ZYMMOB0C9F6, ISPD_ACAM1Q6FAU1, ISPD_ACIAD
B2I2A2, ISPD_ACIBCB0VQH8, ISPD_ACIBSA3M5X8, ISPD_ACIBT
B0V5E6, ISPD_ACIBYC1F763, ISPD_ACIC5B7J4C0, ISPD_ACIF2
B5EMB5, ISPD_ACIF5A3N0G2, ISPD_ACTP2B3H1E1, ISPD_ACTP7
B0BP82, ISPD_ACTPJA6VQY1, ISPD_ACTSZA0KGH5, ISPD_AERHH
Q5E328, ISPD_ALIF1B5FAF7, ISPD_ALIFMB6EKL6, ISPD_ALISL
Q5WLT7, ISPD_ALKCKA6TWL0, ISPD_ALKMQA8MLB1, ISPD_ALKOO
B4RZG5, ISPD_ALTMDO67343, ISPD_AQUAEP69834, ISPD_ARATH
Q5NYJ9, ISPD_AROAEB6YQA2, ISPD_AZOPCA1K644, ISPD_AZOSB
A0R8F7, ISPD_BACAHQ81VV5, ISPD_BACANQ73FC1, ISPD_BACC1
A7GJZ7, ISPD_BACCNQ81J63, ISPD_BACCRQ63HB4, ISPD_BACCZ
Q5L917, ISPD_BACFNQ64P77, ISPD_BACFRQ6HPT2, ISPD_BACHK
Q65PD2, ISPD_BACLDA9VN98, ISPD_BACMKA8F958, ISPD_BACP2
Q06755, ISPD_BACSUQ8A0U8, ISPD_BACTNA7Z0L2, ISPD_BACVZ
Q1LTP8, ISPD_BAUCHB3DTQ9, ISPD_BIFLDQ8G7E2, ISPD_BIFLO
B7GMX1, ISPD_BIFLSQ494E8, ISPD_BLOPBQ7WCW3, ISPD_BORBR
Q7W5C9, ISPD_BORPAA9II44, ISPD_BORPDQ7VZN2, ISPD_BORPE
P57495, ISPD_BUCAIQ8K9D6, ISPD_BUCAPA0K867, ISPD_BURCH
B4EC23, ISPD_BURCJQ0BED6, ISPD_BURCMQ39FB8, ISPD_BURL3
A9AIT5, ISPD_BURM1A3MKM4, ISPD_BURM7A2SBD6, ISPD_BURM9
Q62JI5, ISPD_BURMAA1V500, ISPD_BURMSQ1BHA5, ISPD_BURO1
A3NWE0, ISPD_BURP0Q3JR99, ISPD_BURP1A3NAL9, ISPD_BURP6
Q63T70, ISPD_BURPSQ2SWT6, ISPD_BURTAA4JF20, ISPD_BURVG
B9MJW2, ISPD_CALBDQ8R7S6, ISPD_CALS4A4XLJ3, ISPD_CALS8
Q3A9N7, ISPD_CARHZA3PJQ3, ISPD_CERS1Q3J2K9, ISPD_CERS4
A4WSL5, ISPD_CERS5B9KSH8, ISPD_CERSKQ5L6V2, ISPD_CHLAB
Q3AS33, ISPD_CHLCHQ824I4, ISPD_CHLCVQ253C1, ISPD_CHLFF
Q3B3A7, ISPD_CHLL3Q9PJT1, ISPD_CHLMUB3QP85, ISPD_CHLP8
B3EQ34, ISPD_CHLPBA4SF04, ISPD_CHLPMQ9Z7X5, ISPD_CHLPN
B0B835, ISPD_CHLT2B3QXK8, ISPD_CHLT3Q3KLN6, ISPD_CHLTA
B0BCA0, ISPD_CHLTBQ8KCU3, ISPD_CHLTEO84468, ISPD_CHLTR
Q1QU73, ISPD_CHRSDQ7NYL6, ISPD_CHRVOA8ANW1, ISPD_CITK8
Q97EC9, ISPD_CLOABA7FZ94, ISPD_CLOB1C3KVS6, ISPD_CLOB6
A6LPN9, ISPD_CLOB8B2TIF4, ISPD_CLOBBA5I7N1, ISPD_CLOBH
C1FMX6, ISPD_CLOBJB1IGH9, ISPD_CLOBKA7GJ99, ISPD_CLOBL
B1KTA8, ISPD_CLOBMQ18CD1, ISPD_CLOD6B9DY87, ISPD_CLOK1
A5N4M5, ISPD_CLOK5A0PXS4, ISPD_CLONNQ0TMM2, ISPD_CLOP1
Q8XHQ3, ISPD_CLOPEQ0SQB9, ISPD_CLOPSQ890M1, ISPD_CLOTE
Q487E9, ISPD_COLP3Q6NFC1, ISPD_CORDIQ8FMI3, ISPD_COREF
A4QH60, ISPD_CORGBQ8NMB8, ISPD_CORGLQ4JXJ7, ISPD_CORJK
B1WSY4, ISPD_CROS5A7MJ57, ISPD_CROS8Q472F2, ISPD_CUPPJ
Q6AAV8, ISPD_CUTAKQ47EL2, ISPD_DECARQ3ZAD7, ISPD_DEHM1
A5FP88, ISPD_DEHMBQ3ZWE1, ISPD_DEHMCQ1J200, ISPD_DEIGD
Q9RR90, ISPD_DEIRAA4J0Y3, ISPD_DESRMB5YF77, ISPD_DICT6
A7ZQJ1, ISPD_ECO24B7UHG6, ISPD_ECO27B7MKM1, ISPD_ECO45
B7LEG5, ISPD_ECO55Q8X7Y4, ISPD_ECO57B5Z3A9, ISPD_ECO5E
B7NT91, ISPD_ECO7IB7MYQ2, ISPD_ECO81B7LXF9, ISPD_ECO8A
C4ZZQ1, ISPD_ECOBWB1XCS3, ISPD_ECODHA8A3M6, ISPD_ECOHS
A1AEU1, ISPD_ECOK1Q0TEB1, ISPD_ECOL5Q8FEJ5, ISPD_ECOL6
B1IUT2, ISPD_ECOLCQ46893, ISPD_ECOLIB7N6X7, ISPD_ECOLU
B6I6D7, ISPD_ECOSEB1LQ67, ISPD_ECOSMQ1R7U4, ISPD_ECOUT
B1GYT4, ISPD_ENDTXA4WDV2, ISPD_ENT38B7LWK8, ISPD_ESCF3
Q2J542, ISPD_FRACCQ8R6H2, ISPD_FUSNNQ5L433, ISPD_GEOKA
Q39ZL5, ISPD_GEOMGQ746Z9, ISPD_GEOSLA4IJG4, ISPD_GEOTN
A5G938, ISPD_GEOURQ7NGU6, ISPD_GLOVIQ7VLT5, ISPD_HAEDU
Q4QMP4, ISPD_HAEI8A5UE59, ISPD_HAEIEA5UHG1, ISPD_HAEIG
O05029, ISPD_HAEINQ2SKW7, ISPD_HAHCHQ9KGF8, ISPD_HALH5
A1WWZ0, ISPD_HALHLQ5QUC3, ISPD_IDILOB5XV34, ISPD_KLEP3
A6TD39, ISPD_KLEP7C4Z312, ISPD_LACE2A9KSU6, ISPD_LACP7
C1D558, ISPD_LARHHQ04VR0, ISPD_LEPBJQ04XR1, ISPD_LEPBL
Q72P59, ISPD_LEPICQ8F7A0, ISPD_LEPINQ92F40, ISPD_LISIN
Q724H7, ISPD_LISMFQ8YAB5, ISPD_LISMOB1HNM7, ISPD_LYSSC
Q65Q78, ISPD_MANSMQ604M2, ISPD_METCAB0JUF7, ISPD_MICAN
Q2RFM0, ISPD_MOOTAQ7TW54, ISPD_MYCBOA1KPR8, ISPD_MYCBP
C1AI41, ISPD_MYCBTB8ZUA7, ISPD_MYCLBQ9CCW6, ISPD_MYCLE
B2HJ23, ISPD_MYCMMQ743W5, ISPD_MYCPAA5U8Q7, ISPD_MYCTA
P9WKG8, ISPD_MYCTOP9WKG9, ISPD_MYCTUA0PV29, ISPD_MYCUA
Q5F829, ISPD_NEIG1B4RL14, ISPD_NEIG2A9M0U7, ISPD_NEIM0
Q9JTM3, ISPD_NEIMAQ9JYM4, ISPD_NEIMBA1KUV0, ISPD_NEIMF
Q2GEM3, ISPD_NEOSMQ0AFW3, ISPD_NITECQ82UR9, ISPD_NITEU
Q2Y751, ISPD_NITMUQ3JCS9, ISPD_NITOCQ5Z2R3, ISPD_NOCFA
B2J1D2, ISPD_NOSP7Q8YLX9, ISPD_NOSS1Q5N8G1, ISPD_ORYSJ
Q7U559, ISPD_PARMWB2JGK2, ISPD_PARP8B2T3X2, ISPD_PARPJ
Q6MEE8, ISPD_PARUWQ13Z31, ISPD_PARXLP57953, ISPD_PASMU
Q6D1B3, ISPD_PECASC6DDG2, ISPD_PECCPB4SAG7, ISPD_PELPB
A5D5L4, ISPD_PELTSA9BHR2, ISPD_PETMOQ7N8K7, ISPD_PHOLL
Q6LMT3, ISPD_PHOPRA6KXL8, ISPD_PHOV8B2RJ15, ISPD_PORG3
Q7MUQ9, ISPD_PORGIB4S8U7, ISPD_PROA2A3PBH7, ISPD_PROM0
A8G3G9, ISPD_PROM2A9BE76, ISPD_PROM4A2BVB5, ISPD_PROM5
Q31C80, ISPD_PROM9Q7VDC7, ISPD_PROMAQ7V647, ISPD_PROMM
Q7V2M1, ISPD_PROMPA2BPT7, ISPD_PROMSQ46GW4, ISPD_PROMT
Q48F81, ISPD_PSE14Q15P31, ISPD_PSEA6A6V1F5, ISPD_PSEA7
Q02RA5, ISPD_PSEABP57707, ISPD_PSEAEQ1I648, ISPD_PSEE4
Q4KHF4, ISPD_PSEF5C3K6H8, ISPD_PSEFSA4XWR9, ISPD_PSEMY
A5W827, ISPD_PSEP1Q3KH90, ISPD_PSEPFB0KSC1, ISPD_PSEPG
Q88MF7, ISPD_PSEPKB1JB36, ISPD_PSEPWQ886M1, ISPD_PSESM
Q3IDQ6, ISPD_PSET1Q4ZWQ6, ISPD_PSEU2Q4FR76, ISPD_PSYA2
Q1Q9K8, ISPD_PSYCKQ8XYW3, ISPD_RALN1Q7UM15, ISPD_RHOBA
C0ZPR7, ISPD_RHOE4Q0S890, ISPD_RHOJRC1BAC2, ISPD_RHOOB
Q165P6, ISPD_ROSDOQ1AU08, ISPD_RUBXDA1AX25, ISPD_RUTMC
A4F6W3, ISPD_SACENB5F411, ISPD_SALA4A9MF28, ISPD_SALAR
Q57KJ4, ISPD_SALCHB5FTS5, ISPD_SALDCB5QW18, ISPD_SALEP
B5RDQ3, ISPD_SALG2B4TFW7, ISPD_SALHSB4T457, ISPD_SALNS
Q5PEG1, ISPD_SALPAA9N2D3, ISPD_SALPBC0PXA7, ISPD_SALPC
B5BEY4, ISPD_SALPKQ2S210, ISPD_SALRDB4TTW1, ISPD_SALSV
Q8Z471, ISPD_SALTIQ8ZMF6, ISPD_SALTYA8G9Z2, ISPD_SERP5
A1S4D9, ISPD_SHEAMQ12PZ2, ISPD_SHEDOQ086A8, ISPD_SHEFN
B0TK06, ISPD_SHEHHA3QC79, ISPD_SHELPQ8EBR2, ISPD_SHEON
A8H1S7, ISPD_SHEPAB8CJP8, ISPD_SHEPWA8FST0, ISPD_SHESH
B2TZI4, ISPD_SHIB3Q31XA9, ISPD_SHIBSQ32CI3, ISPD_SHIDS
Q0T1H8, ISPD_SHIF8Q7C093, ISPD_SHIFLQ3YYB5, ISPD_SHISS
Q2NVM4, ISPD_SODGMQ027G1, ISPD_SOLUEQ82GC8, ISPD_STRAW
Q9L0Q8, ISPD_STRCOB4SR88, ISPD_STRM5B2FK90, ISPD_STRMK
Q67JP5, ISPD_SYMTHQ2LUS9, ISPD_SYNASQ3A8C6, ISPD_SYNC1
Q31QF6, ISPD_SYNE7A0LIS2, ISPD_SYNFMQ2JUE5, ISPD_SYNJA
Q5N3T2, ISPD_SYNP6A5GMW9, ISPD_SYNPWQ0I880, ISPD_SYNS3
Q3AWK9, ISPD_SYNS9Q3ALY8, ISPD_SYNSCP74323, ISPD_SYNY3
B7IF61, ISPD_THEABQ47LV0, ISPD_THEFYA6LPA6, ISPD_THEM4
Q9X1B3, ISPD_THEMAB9K8U1, ISPD_THENNA5IMI1, ISPD_THEP1
B1LBT2, ISPD_THESQQ72GN3, ISPD_THET2Q5SLX2, ISPD_THET8
Q8DL91, ISPD_THEVBQ3SK38, ISPD_THIDAC4LBQ9, ISPD_TOLAT
Q118M1, ISPD_TRIEIQ3MAF5, ISPD_TRIV2A5CW51, ISPD_VESOH
B7VK66, ISPD_VIBA3Q9KUJ2, ISPD_VIBCHQ87LQ2, ISPD_VIBPA
Q8DC60, ISPD_VIBVUQ7MHQ4, ISPD_VIBVYQ8D223, ISPD_WIGBR
Q8PLR8, ISPD_XANACQ3BUS8, ISPD_XANC5Q4UTP4, ISPD_XANC8
B0RU03, ISPD_XANCBQ8P9Z1, ISPD_XANCPQ2P1L0, ISPD_XANOM
B2SUA8, ISPD_XANOPQ5GYK6, ISPD_XANORB2I939, ISPD_XYLF2
Q9PDT6, ISPD_XYLFAB0U660, ISPD_XYLFMQ87DY4, ISPD_XYLFT
A7FLX8, ISPD_YERP3B2K577, ISPD_YERPBQ8ZBP6, ISPD_YERPE
A9R119, ISPD_YERPGQ1CLR6, ISPD_YERPNA4TPZ7, ISPD_YERPP
Q66EC3, ISPD_YERPSB1JJF8, ISPD_YERPY

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