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ENZYME entry: EC 2.7.7.64

Accepted Name
UTP-monosaccharide-1-phosphate uridylyltransferase.
Alternative Name(s)
UDP-sugar pyrophosphorylase.
USP.
Reaction catalysed
UTP + a monosaccharide 1-phosphate <=> diphosphate + UDP-monosaccharide
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates.
  • Catalyzes the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity toward monosaccharide 1-phosphates.
  • Mannose 1-phosphate, L-fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates.
Cross-references
BRENDA2.7.7.64
EC2PDB2.7.7.64
ExplorEnz2.7.7.64
PRIAM enzyme-specific profiles2.7.7.64
KEGG Ligand Database for Enzyme Nomenclature2.7.7.64
IUBMB Enzyme Nomenclature2.7.7.64
IntEnz2.7.7.64
MEDLINEFind literature relating to 2.7.7.64
MetaCyc2.7.7.64
Rhea expert-curated reactions2.7.7.64
UniProtKB/Swiss-Prot
Q09WE7, USP1_SOYBN;  Q9C5I1, USP_ARATH;  Q0GZS3, USP_CUCME;  
A2YGP6, USP_ORYSI;  Q5Z8Y4, USP_ORYSJ;  Q5W915, USP_PEA;  

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