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ENZYME entry: EC 2.7.7.68

Accepted Name
2-phospho-L-lactate guanylyltransferase.
Reaction catalysed
(2S)-2-phospholactate + GTP <=> (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate
Comment(s)
  • This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in all methanogenic archaea.
  • Cf. EC 2.7.7.105 and EC 2.7.7.106.
Cross-references
BRENDA2.7.7.68
EC2PDB2.7.7.68
ExplorEnz2.7.7.68
PRIAM enzyme-specific profiles2.7.7.68
KEGG Ligand Database for Enzyme Nomenclature2.7.7.68
IUBMB Enzyme Nomenclature2.7.7.68
IntEnz2.7.7.68
MEDLINEFind literature relating to 2.7.7.68
MetaCyc2.7.7.68
Rhea expert-curated reactions2.7.7.68
UniProtKB/Swiss-Prot
O28218, COFC_ARCFU;  D2RFQ5, COFC_ARCPA;  D3RZQ1, COFC_FERPA;  
B9LQ33, COFC_HALLT;  Q5UXM7, COFC_HALMA;  C7P363, COFC_HALMD;  
B0R6P7, COFC_HALS3;  Q9HNV0, COFC_HALSA;  D2RWE9, COFC_HALTV;  
C7NN78, COFC_HALUD;  D4GVD5, COFC_HALVD;  Q18FK8, COFC_HALWD;  
A6UUS0, COFC_META3;  Q8TQQ2, COFC_METAC;  Q0W6V1, COFC_METAR;  
A7IAF1, COFC_METB6;  Q466A1, COFC_METBF;  Q12WF3, COFC_METBU;  
C7P592, COFC_METFA;  Q2FQJ1, COFC_METHJ;  D5VSX2, COFC_METIM;  
Q58297, COFC_METJA;  Q8TXS3, COFC_METKA;  A2ST69, COFC_METLZ;  
A4G074, COFC_METM5;  A9A8H9, COFC_METM6;  A6VIA6, COFC_METM7;  
Q8PU52, COFC_METMA;  A3CWL3, COFC_METMJ;  Q6M101, COFC_METMP;  
D5E7G9, COFC_METMS;  B8GKC0, COFC_METPE;  D1Z1G0, COFC_METPS;  
D3E2P3, COFC_METRM;  A5UJW5, COFC_METS3;  D3S534, COFC_METSF;  
Q2NFK9, COFC_METST;  O26710, COFC_METTH;  A0B5I5, COFC_METTP;  
C9REF5, COFC_METVM;  A6URA0, COFC_METVS;  D3SYZ8, COFC_NATMM;  
Q3IRF2, COFC_NATPD;  

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