ENZYME entry: EC 2.7.7.68

Accepted Name

2-phospho-L-lactate guanylyltransferase

Reaction catalysed

(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate

Comment(s)

This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in all methanogenic archaea. cf. EC 2.7.7.105 and EC 2.7.7.106.

Cross-references

BRENDA

2.7.7.68

EC2PDB

2.7.7.68

ExplorEnz

2.7.7.68

PRIAM enzyme-specific profiles

2.7.7.68

KEGG Ligand Database for Enzyme Nomenclature

2.7.7.68

IUBMB Enzyme Nomenclature

2.7.7.68

IntEnz

2.7.7.68

MEDLINE

Find literature relating to 2.7.7.68

MetaCyc

2.7.7.68

Rhea expert-curated reactions

2.7.7.68

UniProtKB/Swiss-Prot

O28218, COFC_ARCFU	D2RFQ5, COFC_ARCPA	D3RZQ1, COFC_FERPA
B9LQ33, COFC_HALLT	Q5UXM7, COFC_HALMA	C7P363, COFC_HALMD
B0R6P7, COFC_HALS3	Q9HNV0, COFC_HALSA	D2RWE9, COFC_HALTV
C7NN78, COFC_HALUD	D4GVD5, COFC_HALVD	Q18FK8, COFC_HALWD
A6UUS0, COFC_META3	Q8TQQ2, COFC_METAC	Q0W6V1, COFC_METAR
A7IAF1, COFC_METB6	Q466A1, COFC_METBF	Q12WF3, COFC_METBU
C7P592, COFC_METFA	Q2FQJ1, COFC_METHJ	D5VSX2, COFC_METIM
Q58297, COFC_METJA	Q8TXS3, COFC_METKA	A2ST69, COFC_METLZ
A4G074, COFC_METM5	A9A8H9, COFC_METM6	A6VIA6, COFC_METM7
Q8PU52, COFC_METMA	A3CWL3, COFC_METMJ	Q6M101, COFC_METMP
D5E7G9, COFC_METMS	B8GKC0, COFC_METPE	D1Z1G0, COFC_METPS
D3E2P3, COFC_METRM	A5UJW5, COFC_METS3	D3S534, COFC_METSF
Q2NFK9, COFC_METST	O26710, COFC_METTH	A0B5I5, COFC_METTP
C9REF5, COFC_METVM	A6URA0, COFC_METVS	D3SYZ8, COFC_NATMM
Q3IRF2, COFC_NATPD

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