ENZYME entry: EC 2.7.7.69
Accepted Name |
GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase.
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Alternative Name(s) |
GDP-L-galactose phosphorylase. |
Reaction catalysed |
- GDP-beta-L-galactose + alpha-D-mannose 1-phosphate <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose
- GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose
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Comment(s) |
- This plant enzyme catalyzes the conversion of GDP-beta-L-galactose
and GDP-alpha-D-glucose to beta-L-galactose 1-phosphate and alpha-D-
glucose 1-phosphate, respectively.
- The enzyme can use inorganic phosphate as the cosubstrate,
but several hexose 1-phosphates, including alpha-D-mannose
1-phosphate, alpha-D-glucose 1-phosphate, and alpha-D-galactose
1-phosphate, are better guanylyl acceptors.
- The enzyme's activity on GDP-beta-L-galactose is crucial for the
biosynthesis of L-ascorbate.
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Cross-references |
BRENDA | 2.7.7.69 |
EC2PDB | 2.7.7.69 |
ExplorEnz | 2.7.7.69 |
PRIAM enzyme-specific profiles | 2.7.7.69 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.7.69 |
IUBMB Enzyme Nomenclature | 2.7.7.69 |
IntEnz | 2.7.7.69 |
MEDLINE | Find literature relating to 2.7.7.69 |
MetaCyc | 2.7.7.69 |
Rhea expert-curated reactions | 2.7.7.69 |
UniProtKB/Swiss-Prot |
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