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ENZYME

ENZYME entry: EC 2.7.7.69

Accepted Name
GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase
Alternative Name(s)
GDP-L-galactose phosphorylase
Reaction catalysed
  • alpha-D-mannose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose
  • alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose
Comment(s)
  • This plant enzyme catalyzes the conversion of GDP-beta-L-galactose and GDP-alpha-D-glucose to beta-L-galactose 1-phosphate and alpha-D- glucose 1-phosphate, respectively.
  • The enzyme can use inorganic phosphate as the cosubstrate, but several hexose 1-phosphates, including alpha-D-mannose 1-phosphate, alpha-D-glucose 1-phosphate, and alpha-D-galactose 1-phosphate, are better guanylyl acceptors.
  • The enzyme's activity on GDP-beta-L-galactose is crucial for the biosynthesis of L-ascorbate.
Cross-references
BRENDA2.7.7.69
EC2PDB2.7.7.69
ExplorEnz2.7.7.69
PRIAM enzyme-specific profiles2.7.7.69
KEGG Ligand Database for Enzyme Nomenclature2.7.7.69
IUBMB Enzyme Nomenclature2.7.7.69
IntEnz2.7.7.69
MEDLINEFind literature relating to 2.7.7.69
MetaCyc2.7.7.69
Rhea expert-curated reactions2.7.7.69
UniProtKB/Swiss-Prot
Q8RWE8, GGAP1_ARATHQ9FLP9, GGAP2_ARATH

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