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ENZYME

ENZYME entry: EC 2.7.7.72

Accepted Name
CCA tRNA nucleotidyltransferase
Alternative Name(s)
CCA-adding enzyme
ribonucleic cytidylic cytidylic adenylic pyrophosphorylase
transfer ribonucleic adenylyl (cytidylyl) transferase
transfer RNA adenylyltransferase
transfer-RNA nucleotidyltransferase
tRNA adenylyl(cytidylyl)transferase
tRNA CCA-diphosphorylase
tRNA cytidylyltransferase
tRNA-nucleotidyltransferase
Reaction catalysed
a tRNA precursor + ATP + 2 CTP <=> a tRNA with a 3' CCA end + 3 diphosphate
Comment(s)
  • The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence.
  • The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms.
  • Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition.
  • Formerly EC 2.7.7.21 and EC 2.7.7.25.
Cross-references
BRENDA2.7.7.72
EC2PDB2.7.7.72
ExplorEnz2.7.7.72
PRIAM enzyme-specific profiles2.7.7.72
KEGG Ligand Database for Enzyme Nomenclature2.7.7.72
IUBMB Enzyme Nomenclature2.7.7.72
IntEnz2.7.7.72
MEDLINEFind literature relating to 2.7.7.72
MetaCyc2.7.7.72
Rhea expert-curated reactions2.7.7.72
UniProtKB/Swiss-Prot
Q9P4S5, CCA1_CANGBP21269, CCA1_YEASTA1TUW0, CCA_ACIAC
Q6FA38, CCA_ACIADB7GZN3, CCA_ACIB3B7I3L8, CCA_ACIB5
B2HV23, CCA_ACIBCB0VUU0, CCA_ACIBSA3M767, CCA_ACIBT
B0VBE4, CCA_ACIBYB9MCK1, CCA_ACIETA1W3D0, CCA_ACISJ
A3N0S5, CCA_ACTP2B3GXR2, CCA_ACTP7A6VN94, CCA_ACTSZ
A0KPN1, CCA_AERHHP45749, CCA_AERHYQ9YB04, CCA_AERPE
A4SIG1, CCA_AERS4Q0VMU8, CCA_ALCBSQ5E2K7, CCA_ALIF1
B5FB77, CCA_ALIFMB6EM10, CCA_ALISLQ0ACP8, CCA_ALKEH
B4RVV4, CCA_ALTMDB7GHS8, CCA_ANOFWO28126, CCA_ARCFU
Q5P3T0, CCA_AROAEA1K2Q5, CCA_AZOSBC1DIX6, CCA_AZOVD
C3P5Q6, CCA_BACAAC3L8Q3, CCA_BACACQ81ST6, CCA_BACAN
B7JH21, CCA_BACC0Q73AV7, CCA_BACC1B7IPB4, CCA_BACC2
C1EN33, CCA_BACC3B7HHU0, CCA_BACC4B7HL50, CCA_BACC7
A7GN74, CCA_BACCNB9IVQ9, CCA_BACCQQ81FP0, CCA_BACCR
Q63DJ6, CCA_BACCZQ6HL19, CCA_BACHKQ65I54, CCA_BACLD
A9VME7, CCA_BACMKA8FEH9, CCA_BACP2P42977, CCA_BACSU
A7Z5Z6, CCA_BACVZQ1LSL7, CCA_BAUCHQ7U350, CCA_BLOFL
Q493X4, CCA_BLOPBQ7U391, CCA_BORBRQ7U367, CCA_BORPA
Q7U358, CCA_BORPEB8D8L9, CCA_BUCA5P57169, CCA_BUCAI
Q8KA53, CCA_BUCAPB8D6X3, CCA_BUCATQ89B06, CCA_BUCBP
Q058D0, CCA_BUCCCB1YPB3, CCA_BURA4A0KBA2, CCA_BURCH
B4E8K1, CCA_BURCJQ0BB41, CCA_BURCMQ39C44, CCA_BURL3
A9ABP3, CCA_BURM1A3MRJ1, CCA_BURM7A2S800, CCA_BURM9
Q62EU1, CCA_BURMAA1V7S8, CCA_BURMSB1JZZ7, CCA_BURO0
Q1BST9, CCA_BURO1A3NQD4, CCA_BURP0A3N4P2, CCA_BURP6
Q63YC3, CCA_BURPSA4JIK4, CCA_BURVGQ7MBF4, CCA_CHRVO
A8APT7, CCA_CITK8A9KEZ9, CCA_COXBNA9NAS1, CCA_COXBR
Q820V9, CCA_COXBUA7MJU1, CCA_CROS8Q1LS11, CCA_CUPMC
Q0KF16, CCA_CUPNHQ476S9, CCA_CUPPJB2AGH1, CCA_CUPTR
Q477X0, CCA_DECARA7ZRT7, CCA_ECO24B7UIW4, CCA_ECO27
B7MAD3, CCA_ECO45B7LGZ2, CCA_ECO55Q8XBL4, CCA_ECO57
B5YR96, CCA_ECO5EB7NJR9, CCA_ECO7IB7N0K6, CCA_ECO81
B7LZK6, CCA_ECO8AC4ZQX3, CCA_ECOBWB1XG61, CCA_ECODH
A8A4L0, CCA_ECOHSA1AFX8, CCA_ECOK1Q0TD50, CCA_ECOL5
Q8CXX6, CCA_ECOL6B1IRR0, CCA_ECOLCP06961, CCA_ECOLI
B7ND45, CCA_ECOLUB6I427, CCA_ECOSEB1LF48, CCA_ECOSM
Q1R6S5, CCA_ECOUTC5BHG5, CCA_EDWI9A4WEI8, CCA_ENT38
Q834S5, CCA_ENTFAB2VGJ4, CCA_ERWT9B7LQD4, CCA_ESCF3
Q47907, CCA_FRANOQ14JW7, CCA_FRAT1A0Q8A2, CCA_FRATN
Q5NIG4, CCA_FRATTQ5KXX0, CCA_GEOKAQ7SIB1, CCA_GEOSE
C5D3B5, CCA_GEOSWA4IQ63, CCA_GEOTNQ9L7A3, CCA_HAEDU
A5UCK0, CCA_HAEIEA5UJ23, CCA_HAEIGP45269, CCA_HAEIN
Q2SM94, CCA_HAHCHA1WZI2, CCA_HALHLB9LS95, CCA_HALLT
Q5V030, CCA_HALMAB0R2Q7, CCA_HALS3Q9HSP6, CCA_HALSA
C4K6G4, CCA_HAMD5A4G969, CCA_HERARQ31J37, CCA_HYDCU
Q5QY23, CCA_IDILOA6T2Y3, CCA_JANMAB5XU35, CCA_KLEP3
A6TE35, CCA_KLEP7Q5FKF0, CCA_LACACB3WE84, CCA_LACCB
Q1G9U3, CCA_LACDAQ049Z4, CCA_LACDBQ043S5, CCA_LACGA
A8YV39, CCA_LACH4Q74JK7, CCA_LACJOQ9CFC2, CCA_LACLA
A2RJT1, CCA_LACLMQ02Y22, CCA_LACLSQ039G0, CCA_LACP3
Q88W02, CCA_LACPLC1DAG2, CCA_LARHHQ38WX5, CCA_LATSS
Q5X1E5, CCA_LEGPAQ5ZRX9, CCA_LEGPHQ5WT58, CCA_LEGPL
B1Y634, CCA_LEPCPB1MYC1, CCA_LEUCKQ03Y57, CCA_LEUMM
Q03S97, CCA_LEVBAQ1WU19, CCA_LIGS1B2GC39, CCA_LIMF3
A5VJK7, CCA_LIMRDB2G721, CCA_LIMRJQ92AA3, CCA_LISIN
C1KWK5, CCA_LISMCQ71YB0, CCA_LISMFB8DC21, CCA_LISMH
Q8Y5Z8, CCA_LISMOA0AK10, CCA_LISW6Q65Q41, CCA_MANSM
A1U5G5, CCA_MARN8Q8TGX2, CCA_METACA7I912, CCA_METB6
Q46AZ4, CCA_METBFQ60CQ4, CCA_METCAQ1GZ11, CCA_METFK
Q58511, CCA_METJAQ8TGY5, CCA_METKAA4FXY2, CCA_METM5
A6VFP0, CCA_METM7Q8PZM3, CCA_METMAQ6LYP1, CCA_METMP
O26684, CCA_METTHQ74NA6, CCA_NANEQQ5F8K9, CCA_NEIG1
B4RLV5, CCA_NEIG2A9LZC1, CCA_NEIM0Q9JUB2, CCA_NEIMA
Q9JZ88, CCA_NEIMBA1KU50, CCA_NEIMFQ0AIP2, CCA_NITEC
Q82U82, CCA_NITEUQ2Y681, CCA_NITMUQ3JE31, CCA_NITOC
Q8EQD6, CCA_OCEIHB2JIM3, CCA_PARP8B2T6V1, CCA_PARPJ
Q9CP21, CCA_PASMUQ6D160, CCA_PECASC6DDL7, CCA_PECCP
Q03F94, CCA_PEDPAQ7MAZ9, CCA_PHOLLQ6LV05, CCA_PHOPR
Q6L1N2, CCA_PICTOA1VSY7, CCA_POLNAB4EW50, CCA_PROMH
Q48NU4, CCA_PSE14Q15QQ0, CCA_PSEA6A6UZ87, CCA_PSEA7
B7V4H0, CCA_PSEA8Q02TH9, CCA_PSEABQ9I5V3, CCA_PSEAE
Q1IG27, CCA_PSEE4Q4K4W8, CCA_PSEF5C3K334, CCA_PSEFS
A4XZK2, CCA_PSEMYA5VXI8, CCA_PSEP1Q3K5S5, CCA_PSEPF
B0KJ86, CCA_PSEPGQ88QU2, CCA_PSEPKB1JDY1, CCA_PSEPW
Q88A53, CCA_PSESMQ4ZMF8, CCA_PSEU2A1SRC9, CCA_PSYIN
Q9V2H1, CCA_PYRABQ8ZTC3, CCA_PYRAEQ8TH22, CCA_PYRFU
O74081, CCA_PYRHOA1RS16, CCA_PYRILB1Y9T4, CCA_PYRNV
Q8Y395, CCA_RALSOQ97Z92, CCA_SACS2P77978, CCA_SACSH
B5F6A0, CCA_SALA4A9MPV9, CCA_SALARQ57JQ5, CCA_SALCH
B5FHT9, CCA_SALDCB5QZ40, CCA_SALEPB5REG2, CCA_SALG2
B4TI55, CCA_SALHSB4T674, CCA_SALNSQ5PC82, CCA_SALPA
A9N5Y2, CCA_SALPBC0PYX7, CCA_SALPCB5BG15, CCA_SALPK
B4TVT8, CCA_SALSVQ8Z3M9, CCA_SALTIQ8ZLY4, CCA_SALTY
A8GJU7, CCA_SERP5B8EBU8, CCA_SHEB2A3D1R1, CCA_SHEB5
A6WKL1, CCA_SHEB8A9L5J0, CCA_SHEB9Q12KC4, CCA_SHEDO
Q07YU1, CCA_SHEFNA3QBN1, CCA_SHELPA8H161, CCA_SHEPA
B8CJF9, CCA_SHEPWA0KZT1, CCA_SHESAA8FS72, CCA_SHESH
Q0HG49, CCA_SHESMQ0HSE2, CCA_SHESRB1KHF1, CCA_SHEWM
B2U1G0, CCA_SHIB3Q31WX9, CCA_SHIBSQ32BQ8, CCA_SHIDS
Q0T0K7, CCA_SHIF8Q821A6, CCA_SHIFLQ3YXI6, CCA_SHISS
Q2NWE2, CCA_SODGMA7X2F4, CCA_STAA1Q2YY49, CCA_STAAB
Q5HFW6, CCA_STAACA6QH08, CCA_STAAEQ99U32, CCA_STAAM
Q7A5K2, CCA_STAANQ6GGV2, CCA_STAARQ6G9A5, CCA_STAAS
A8Z437, CCA_STAATQ8NWP0, CCA_STAAWB9DNX1, CCA_STACT
Q5HP86, CCA_STAEQQ8CP70, CCA_STAESQ4L6G1, CCA_STAHJ
Q49XR3, CCA_STAS1Q8E4J0, CCA_STRA3Q8DYY1, CCA_STRA5
A8AX96, CCA_STRGCB4SIY9, CCA_STRM5B2FUP5, CCA_STRMK
Q8DUL8, CCA_STRMUQ9A0A5, CCA_STRP1P0DA18, CCA_STRP3
B5E6J9, CCA_STRP4Q5XCN7, CCA_STRP6Q8P1E3, CCA_STRP8
Q1JCB2, CCA_STRPBQ1JM96, CCA_STRPCQ1JHE0, CCA_STRPD
Q1J760, CCA_STRPFA2RF34, CCA_STRPGQ48U40, CCA_STRPM
Q97PP9, CCA_STRPNP0DA19, CCA_STRPQB2IR74, CCA_STRPS
Q8CWQ3, CCA_STRR6A4W0U8, CCA_STRS2A3CMU4, CCA_STRSV
A4VUK6, CCA_STRSYQ5M153, CCA_STRT1Q5M5P1, CCA_STRT2
Q03M28, CCA_STRTDB9DRX9, CCA_STRU0Q4J9A0, CCA_SULAC
C3N558, CCA_SULIAC4KGR1, CCA_SULIKC3MPH6, CCA_SULIL
C3MYG4, CCA_SULIMC3NHZ5, CCA_SULINC3NDQ6, CCA_SULIY
Q973E7, CCA_SULTOC5BPQ5, CCA_TERTTQ9HI95, CCA_THEAC
Q9V302, CCA_THEAIC5A3V9, CCA_THEGJQ5JJ38, CCA_THEKO
Q97CI4, CCA_THEVOB8GUR8, CCA_THISHC4LB55, CCA_TOLAT
C5CNM3, CCA_VARPSA1WHX2, CCA_VEREIA7MWN9, CCA_VIBC1
A5F5I2, CCA_VIBC3Q9KPC6, CCA_VIBCHC3LQY9, CCA_VIBCM
Q87SK9, CCA_VIBPAQ8CWL6, CCA_VIBVUQ7M7K5, CCA_VIBVY
Q8D2W4, CCA_WIGBRQ8PPG9, CCA_XANACQ3BXK9, CCA_XANC5
Q4UYN8, CCA_XANC8B0RNU6, CCA_XANCBQ8P5D4, CCA_XANCP
Q2NZ41, CCA_XANOMB2I9I0, CCA_XYLF2Q9PDL7, CCA_XYLFA
B0U6J4, CCA_XYLFMQ87DS9, CCA_XYLFTA1JQW2, CCA_YERE8
A7FE75, CCA_YERP3Q1C370, CCA_YERPAB2K2H9, CCA_YERPB
Q8ZI64, CCA_YERPEA9R7D9, CCA_YERPGQ1CMD8, CCA_YERPN
A4THT5, CCA_YERPPQ665U9, CCA_YERPSB1JM22, CCA_YERPY
Q96Q11, TRNT1_HUMANQ8K1J6, TRNT1_MOUSE

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-