A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.7.7.79
| Accepted Name |
|---|
| tRNA(His) guanylyltransferase.
|
| Alternative Name(s) |
|---|
| Histidine tRNA guanylyltransferase. |
| Reaction catalysed |
|---|
| p-tRNA(His) + ATP + GTP + H(2)O <=> pG-P-tRNA(His) + AMP + 2 diphosphate |
| Comment(s) |
|---|
- In eukarya an additional guanosine residue is added post-
transcriptionally to the 5'-end of tRNA(His) molecules.
- The addition occurs opposite a universally conserved adenosine(73)
and is thus the result of a non-templated 3'-5' addition reaction.
- The additional guanosine residue is an important determinant for
aminoacylation by EC 6.1.1.21.
- The enzyme requires a divalent cation for activity.
- ATP activation is not required when the substrate contains a
5'-triphosphate (ppp-tRNA(His)).
|
| Cross-references |
|---|
| BRENDA | 2.7.7.79 |
| EC2PDB | 2.7.7.79 |
| ExplorEnz | 2.7.7.79 |
| PRIAM enzyme-specific profiles | 2.7.7.79 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.7.79 |
| IUBMB Enzyme Nomenclature | 2.7.7.79 |
| IntEnz | 2.7.7.79 |
| MEDLINE | Find literature relating to 2.7.7.79 |
| MetaCyc | 2.7.7.79 |
| UniProtKB/Swiss-Prot |
| F4IRQ5, THG1_ARATH; | Q75DJ3, THG1_ASHGO; | Q05B50, THG1_BOVIN; |
| Q6FPX3, THG1_CANGA; | Q6BKD4, THG1_DEBHA; | Q54E29, THG1_DICDI; |
| Q9V3N8, THG1_DROME; | Q9NWX6, THG1_HUMAN; | Q6CW75, THG1_KLULA; |
| Q9CY52, THG1_MOUSE; | Q7SDM8, THG1_NEUCR; | Q5M965, THG1_RAT; |
| Q9Y7T3, THG1_SCHPO; | P53215, THG1_YEAST; | F4ISV6, THG2_ARATH; |
|
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