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ENZYME

ENZYME entry: EC 2.7.7.79

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.79
Accepted Name
tRNA(His) guanylyltransferase
Alternative Name(s)
histidine tRNA guanylyltransferase
Reaction catalysed
a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)
Comment(s)
  • In eukarya an additional guanosine residue is added post- transcriptionally to the 5'-end of tRNA(His) molecules.
  • The addition occurs opposite a universally conserved adenosine(73) and is thus the result of a non-templated 3'-5' addition reaction.
  • The additional guanosine residue is an important determinant for aminoacylation by EC 6.1.1.21.
  • The enzyme requires a divalent cation for activity.
  • ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNA(His)).
Cross-references
BRENDA2.7.7.79
EC2PDB2.7.7.79
ExplorEnz2.7.7.79
KEGG Ligand Database for Enzyme Nomenclature2.7.7.79
IUBMB Enzyme Nomenclature2.7.7.79
MEDLINEFind literature relating to 2.7.7.79
MetaCyc2.7.7.79
Rhea expert-curated reactions2.7.7.79
UniProtKB/Swiss-Prot
F4IRQ5, THG1_ARATHQ05B50, THG1_BOVINQ6FPX3, THG1_CANGA
Q6BKD4, THG1_DEBHAQ54E29, THG1_DICDIQ9V3N8, THG1_DROME
Q75DJ3, THG1_EREGSQ9NWX6, THG1_HUMANQ6CW75, THG1_KLULA
Q9CY52, THG1_MOUSEQ7SDM8, THG1_NEUCRQ5M965, THG1_RAT
Q9Y7T3, THG1_SCHPOP53215, THG1_YEASTF4ISV6, THG2_ARATH

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