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ENZYME entry: EC 2.7.7.79

Accepted Name
tRNA(His) guanylyltransferase.
Alternative Name(s)
histidine tRNA guanylyltransferase.
Reaction catalysed
a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)
Comment(s)
  • In eukarya an additional guanosine residue is added post- transcriptionally to the 5'-end of tRNA(His) molecules.
  • The addition occurs opposite a universally conserved adenosine(73) and is thus the result of a non-templated 3'-5' addition reaction.
  • The additional guanosine residue is an important determinant for aminoacylation by EC 6.1.1.21.
  • The enzyme requires a divalent cation for activity.
  • ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNA(His)).
Cross-references
BRENDA2.7.7.79
EC2PDB2.7.7.79
ExplorEnz2.7.7.79
PRIAM enzyme-specific profiles2.7.7.79
KEGG Ligand Database for Enzyme Nomenclature2.7.7.79
IUBMB Enzyme Nomenclature2.7.7.79
IntEnz2.7.7.79
MEDLINEFind literature relating to 2.7.7.79
MetaCyc2.7.7.79
Rhea expert-curated reactions2.7.7.79
UniProtKB/Swiss-Prot
F4IRQ5, THG1_ARATH;  Q75DJ3, THG1_ASHGO;  Q05B50, THG1_BOVIN;  
Q6FPX3, THG1_CANGA;  Q6BKD4, THG1_DEBHA;  Q54E29, THG1_DICDI;  
Q9V3N8, THG1_DROME;  Q9NWX6, THG1_HUMAN;  Q6CW75, THG1_KLULA;  
Q9CY52, THG1_MOUSE;  Q7SDM8, THG1_NEUCR;  Q5M965, THG1_RAT;  
Q9Y7T3, THG1_SCHPO;  P53215, THG1_YEAST;  F4ISV6, THG2_ARATH;  

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