Expasy logo

ENZYME

ENZYME entry: EC 2.7.7.84

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.84
Accepted Name
2'-5' oligoadenylate synthase
Reaction catalysed
3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate
Comment(s)
  • The enzyme is activated by binding to double-stranded RNA.
  • The resulting product binds to and activates RNase L, which subsequently degrades the RNA.
  • Oligoadenylates of chain lengths 2, 4 and 5 are also produced.
  • The dimer does not have any known biological activity.
Cross-references
BRENDA2.7.7.84
EC2PDB2.7.7.84
ExplorEnz2.7.7.84
KEGG Ligand Database for Enzyme Nomenclature2.7.7.84
IUBMB Enzyme Nomenclature2.7.7.84
MEDLINEFind literature relating to 2.7.7.84
MetaCyc2.7.7.84
Rhea expert-curated reactions2.7.7.84
UniProtKB/Swiss-Prot
P11928, OAS1A_MOUSEQ05961, OAS1A_RATP00973, OAS1_HUMAN
Q29599, OAS1_PIGF1N3B8, OAS2_BOVINP29728, OAS2_HUMAN
E9Q9A9, OAS2_MOUSEQ5MYU0, OAS2_RATQ9Y6K5, OAS3_HUMAN
Q8VI93, OAS3_MOUSEQ5MYT7, OAS3_RATQ9Z2F2, OASL2_MOUSE
Q5MYT9, OASL2_RAT

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-