ENZYME entry: EC 2.7.7.84
Accepted Name |
2'-5' oligoadenylate synthase.
|
Reaction catalysed |
3 ATP <=> pppA2'p5'A2'p5'A + 2 diphosphate |
Comment(s) |
- The enzyme is activated by binding to double-stranded RNA.
- The resulting product binds to and activates RNase L, which
subsequently degrades the RNA.
- Oligoadenylates of chain lengths 2, 4 and 5 are also produced.
- The dimer does not have any known biological activity.
|
Cross-references |
BRENDA | 2.7.7.84 |
EC2PDB | 2.7.7.84 |
ExplorEnz | 2.7.7.84 |
PRIAM enzyme-specific profiles | 2.7.7.84 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.7.84 |
IUBMB Enzyme Nomenclature | 2.7.7.84 |
IntEnz | 2.7.7.84 |
MEDLINE | Find literature relating to 2.7.7.84 |
MetaCyc | 2.7.7.84 |
Rhea expert-curated reactions | 2.7.7.84 |
UniProtKB/Swiss-Prot |
P11928, OAS1A_MOUSE; | Q05961, OAS1A_RAT; | P00973, OAS1_HUMAN; |
Q29599, OAS1_PIG; | F1N3B8, OAS2_BOVIN; | P29728, OAS2_HUMAN; |
E9Q9A9, OAS2_MOUSE; | Q5MYU0, OAS2_RAT; | Q9Y6K5, OAS3_HUMAN; |
Q8VI93, OAS3_MOUSE; | Q5MYT7, OAS3_RAT; | Q9Z2F2, OASL2_MOUSE; |
Q5MYT9, OASL2_RAT; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.7.-
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