ENZYME entry: EC 2.7.7.85

PURL: https://purl.expasy.org/enzyme/EC/2.7.7.85

Accepted Name

diadenylate cyclase

Alternative Name(s)

cyclic-di-AMP synthase

Reaction catalysed

2 ATP = 3',3'-c-di-AMP + 2 diphosphate

Comment(s)

Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule.
The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.

Cross-references

BRENDA

2.7.7.85

EC2PDB

2.7.7.85

ExplorEnz

2.7.7.85

KEGG Ligand Database for Enzyme Nomenclature

2.7.7.85

IUBMB Enzyme Nomenclature

2.7.7.85

MEDLINE

Find literature relating to 2.7.7.85

MetaCyc

2.7.7.85

Rhea expert-curated reactions

2.7.7.85

UniProtKB/Swiss-Prot

Q29450, ADCY7_BOVIN	P51828, ADCY7_HUMAN	P51829, ADCY7_MOUSE
Q45589, CDAA_BACSU	O31854, CDAS_BACSU	D5TM67, CDAS_BACT1
P0DXA3, CDNB_ESCAL	D7Y2H2, CDNC_ECOM1	P0DTF7, CDND_PSEAI
P0DSP2, CDNE_ELIME	Q89Y83, CDNG_BRADU	P0DXC0, CGLR3_STYPI
A0A0H3GM48, DACA_LISM4	Q8Y5E4, DACA_LISMO	P47351, DACB_MYCGE
P75528, DACB_MYCPN	D4GZM5, DACZ_HALVD	Q58408, DACZ_METJA
A3DGC7, DISA_ACET2	A0LRE3, DISA_ACIC1	C3P9M9, DISA_BACAA
C3LJ56, DISA_BACAC	A0R8F5, DISA_BACAH	Q81VV7, DISA_BACAN
B7JK90, DISA_BACC0	Q73FC3, DISA_BACC1	B7ISZ3, DISA_BACC2
C1ET13, DISA_BACC3	B7HJ22, DISA_BACC4	B7HQR7, DISA_BACC7
B9IZG8, DISA_BACCQ	Q81J64, DISA_BACCR	Q63HB6, DISA_BACCZ
Q6HPT4, DISA_BACHK	Q65PD4, DISA_BACLD	A9VN96, DISA_BACMK
A8F956, DISA_BACP2	P37573, DISA_BACSU	C5C1B3, DISA_BEUC1
Q3A9N3, DISA_CARHZ	Q97EC6, DISA_CLOAB	A7FZ95, DISA_CLOB1
C3KVS9, DISA_CLOB6	A6LPN7, DISA_CLOB8	B2UY85, DISA_CLOBA
B2TIF1, DISA_CLOBB	A5I7N4, DISA_CLOBH	C1FNB1, DISA_CLOBJ
B1IGI2, DISA_CLOBK	A7GJA2, DISA_CLOBL	B1KTB1, DISA_CLOBM
Q18CB2, DISA_CLOD6	A5N4M2, DISA_CLOK5	Q8XHQ0, DISA_CLOPE
Q0SQB6, DISA_CLOPS	Q890L8, DISA_CLOTE	Q8FMH9, DISA_COREF
A4QH66, DISA_CORGB	Q8NMB2, DISA_CORGL	Q6AAZ9, DISA_CUTAK
Q0RBN2, DISA_FRAAA	Q2J537, DISA_FRACC	Q8RGW9, DISA_FUSNN
Q9KGG0, DISA_HALH5	A6W5K2, DISA_KINRD	A0QAA9, DISA_MYCA1
Q7TW52, DISA_MYCBO	A1KPS2, DISA_MYCBP	C1AI45, DISA_MYCBT
Q743W9, DISA_MYCPA	A0R564, DISA_MYCS2	A5U8R1, DISA_MYCTA
P9WNW4, DISA_MYCTO	P9WNW5, DISA_MYCTU	A8LF79, DISA_PARS2
Q5WLT9, DISA_SHOC1	Q82EA6, DISA_STRAW	Q9X8L6, DISA_STRCO
B1VSK3, DISA_STRGG	Q67JP1, DISA_SYMTH	Q9WY43, DISA_THEMA
B9K6S9, DISA_THENN	A5IKM1, DISA_THEP1

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