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ENZYME entry: EC 2.7.7.86

Accepted Name
Cyclic GMP-AMP synthase.
Reaction catalysed
ATP + GTP <=> 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5')
Comment(s)
Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
Cross-references
BRENDA2.7.7.86
EC2PDB2.7.7.86
ExplorEnz2.7.7.86
PRIAM enzyme-specific profiles2.7.7.86
KEGG Ligand Database for Enzyme Nomenclature2.7.7.86
IUBMB Enzyme Nomenclature2.7.7.86
IntEnz2.7.7.86
MEDLINEFind literature relating to 2.7.7.86
MetaCyc2.7.7.86
Rhea expert-curated reactions2.7.7.86
UniProtKB/Swiss-Prot
E1BGN7, CGAS_BOVIN;  Q8N884, CGAS_HUMAN;  Q8C6L5, CGAS_MOUSE;  
A7SFB5, CGAS_NEMVE;  I3LM39, CGAS_PIG;  A8DYP7, CGLR2_DROME;  
D6WI29, CGLR_TRICA;  

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