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ENZYME

ENZYME entry: EC 2.7.7.96

Accepted Name
ADP-D-ribose pyrophosphorylase
Alternative Name(s)
diphosphate adenylyltransferase
diphosphate--ADP-D-ribose adenylyltransferase
NUDIX5
Reaction catalysed
ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate
Comment(s)
  • The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling.
  • The reaction is dependent on the presence of diphosphate.
  • In its absence the enzyme catalyzes the reaction of EC 3.6.1.13. cf. EC 2.7.7.35.
Cross-references
BRENDA2.7.7.96
EC2PDB2.7.7.96
ExplorEnz2.7.7.96
PRIAM enzyme-specific profiles2.7.7.96
KEGG Ligand Database for Enzyme Nomenclature2.7.7.96
IUBMB Enzyme Nomenclature2.7.7.96
IntEnz2.7.7.96
MEDLINEFind literature relating to 2.7.7.96
MetaCyc2.7.7.96
Rhea expert-curated reactions2.7.7.96
UniProtKB/Swiss-Prot
Q9UKK9, NUDT5_HUMANQ9JKX6, NUDT5_MOUSEQ5RCY2, NUDT5_PONAB
Q6AY63, NUDT5_RAT

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