ID   2.7.7.97
DE   3-hydroxy-4-methylanthranilate adenylyltransferase.
AN   4-MHA-activating enzyme.
AN   actinomycin synthase I.
CA   3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-
CA   methylanthranilyl-5'-AMP + diphosphate.
CC   -!- The enzyme, characterized from the bacteria Streptomyces anulatus and
CC       Streptosporangium sibiricum, activates 3-hydroxy-4-
CC       methylanthranilate, a precursor of actinomycin antibiotics and the
CC       antitumor antibiotic sibiromycin, to an adenylate form, so it can be
CC       loaded onto a dedicated aryl-carrier protein.
DR   P80435, MHAA_STRAQ ;  C0LTL9, MHAA_STRSJ ;
//