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ENZYME

ENZYME entry: EC 2.7.8.17

Accepted Name
UDP-N-acetylglucosamine--lysosomal-enzyme N-acetylglucosaminephosphotransferase
Alternative Name(s)
N-acetylglucosaminylphosphotransferase
Reaction catalysed
N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP
Comment(s)
Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes.
Cross-references
BRENDA2.7.8.17
EC2PDB2.7.8.17
ExplorEnz2.7.8.17
PRIAM enzyme-specific profiles2.7.8.17
KEGG Ligand Database for Enzyme Nomenclature2.7.8.17
IUBMB Enzyme Nomenclature2.7.8.17
IntEnz2.7.8.17
MEDLINEFind literature relating to 2.7.8.17
MetaCyc2.7.8.17
Rhea expert-curated reactions2.7.8.17
UniProtKB/Swiss-Prot
Q5RGJ8, GNPTA_DANREQ3T906, GNPTA_HUMANQ69ZN6, GNPTA_MOUSE

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