ID   2.7.8.26
DE   adenosylcobinamide-GDP ribazoletransferase.
AN   cobalamin (5'-phosphate) synthase.
AN   cobalamin-5'-phosphate synthase.
AN   cobalamin synthase.
CA   (1) adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin
CA   + GMP + H(+).
CA   (2) adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate =
CA   adenosylcob(III)alamin 5'-phosphate + GMP + H(+).
CC   -!- In Salmonella typhimurium LT2, under anaerobic conditions, CobU
CC       (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21),
CC       CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the
CC       nucleotide loop assembly pathway, which convert adenosylcobinamide
CC       (AdoCbi) into adenosylcobalamin (AdoCbl).
CC   -!- CobT and CobC are involved in 5,6-dimethylbenzimidazole activation
CC       whereby 5,6-dimethylbenzimidazole is converted to its riboside,
CC       alpha-ribazole.
CC   -!- The second branch of the nucleotide loop assembly pathway is the
CC       cobinamide (Cbi) activation branch where AdoCbi or
CC       adenosylcobinamide-phosphate is converted to the activated
CC       intermediate AdoCbi-GDP by the bifunctional enzyme CobU.
CC   -!- CobS catalyzes the final step in adenosylcobalamin biosynthesis,
CC       which is the condensation of AdoCbi-GDP with alpha-ribazole to yield
CC       adenosylcobalamin.
DR   O30198, COBS1_ARCFU;  O27961, COBS2_ARCFU;  A3DK68, COBS_ACET2 ;
DR   B2HZL6, COBS_ACIBC ;  A3M596, COBS_ACIBT ;  Q21V77, COBS_ALBFT ;
DR   Q0A4T1, COBS_ALKEH ;  A6TU75, COBS_ALKMQ ;  A8MIW2, COBS_ALKOO ;
DR   B9JW08, COBS_ALLAM ;  Q5P2R7, COBS_AROAE ;  A8ID91, COBS_AZOC5 ;
DR   Q89Q75, COBS_BRADU ;  C0Z7H6, COBS_BREBN ;  B2S5A0, COBS_BRUA1 ;
DR   Q2YNK8, COBS_BRUA2 ;  A6X1H1, COBS_BRUA4 ;  Q57DP0, COBS_BRUAB ;
DR   A9MAN9, COBS_BRUC2 ;  C0RIJ9, COBS_BRUMB ;  Q8YGQ8, COBS_BRUME ;
DR   A5VQ44, COBS_BRUO2 ;  B0CLJ1, COBS_BRUSI ;  Q8G156, COBS_BRUSU ;
DR   Q8RCN8, COBS_CALS4 ;  Q3AE01, COBS_CARHZ ;  Q3ARQ6, COBS_CHLCH ;
DR   B3QNS4, COBS_CHLP8 ;  B3EJP7, COBS_CHLPB ;  A4SEC9, COBS_CHLPM ;
DR   Q8KDU6, COBS_CHLTE ;  A8AER0, COBS_CITK8 ;  Q97JA2, COBS_CLOAB ;
DR   A7FS72, COBS_CLOB1 ;  C3L2A5, COBS_CLOB6 ;  A6LSW5, COBS_CLOB8 ;
DR   B2UXE0, COBS_CLOBA ;  B2TPF2, COBS_CLOBB ;  A5I013, COBS_CLOBH ;
DR   C1FUP2, COBS_CLOBJ ;  B1IGK6, COBS_CLOBK ;  A7GBL1, COBS_CLOBL ;
DR   B1KX15, COBS_CLOBM ;  Q180T5, COBS_CLOD6 ;  B9E675, COBS_CLOK1 ;
DR   A5N2J8, COBS_CLOK5 ;  A0Q0K0, COBS_CLONN ;  Q0TRK3, COBS_CLOP1 ;
DR   Q8XLK5, COBS_CLOPE ;  Q0STX5, COBS_CLOPS ;  Q897L5, COBS_CLOTE ;
DR   Q6NG92, COBS_CORDI ;  Q8FNQ1, COBS_COREF ;  A4QFR6, COBS_CORGB ;
DR   Q8NNJ7, COBS_CORGL ;  Q9RYR9, COBS_DEIRA ;  Q24VN7, COBS_DESHY ;
DR   A4J804, COBS_DESRM ;  Q72DL5, COBS_DESVH ;  B8DRQ3, COBS_DESVM ;
DR   A1VF70, COBS_DESVV ;  A7ZNF6, COBS_ECO24 ;  B7UT21, COBS_ECO27 ;
DR   B7MDB8, COBS_ECO45 ;  B7L917, COBS_ECO55 ;  Q8X8U9, COBS_ECO57 ;
DR   B5YSS1, COBS_ECO5E ;  B7NR82, COBS_ECO7I ;  B7MWP9, COBS_ECO81 ;
DR   B7M3C8, COBS_ECO8A ;  C4ZQQ5, COBS_ECOBW ;  B1X6T0, COBS_ECODH ;
DR   A8A1K6, COBS_ECOHS ;  Q0TGE0, COBS_ECOL5 ;  Q8FGA4, COBS_ECOL6 ;
DR   B1IZQ8, COBS_ECOLC ;  P36561, COBS_ECOLI ;  B7NC26, COBS_ECOLU ;
DR   B6I829, COBS_ECOSE ;  B1LPV6, COBS_ECOSM ;  A7HMT2, COBS_FERNB ;
DR   Q2J8A4, COBS_FRACC ;  Q8R666, COBS_FUSNN ;  B9LZU3, COBS_GEODF ;
DR   Q5KXP1, COBS_GEOKA ;  C5D3K0, COBS_GEOSW ;  A4IQD8, COBS_GEOTN ;
DR   Q9KCH9, COBS_HALH5 ;  B9LRL5, COBS_HALLT ;  Q9HPL2, COBS_HALSA ;
DR   Q18KB3, COBS_HALWD ;  A9AYY2, COBS_HERA2 ;  B5XPI1, COBS_KLEP3 ;
DR   A6TBB1, COBS_KLEP7 ;  C5CE71, COBS_KOSOT ;  A9KMP0, COBS_LACP7 ;
DR   C1D6F9, COBS_LARHH ;  B0SFE6, COBS_LEPBA ;  B0SNZ5, COBS_LEPBP ;
DR   B1Y854, COBS_LEPCP ;  Q72M34, COBS_LEPIC ;  Q8EYK8, COBS_LEPIN ;
DR   Q92CQ9, COBS_LISIN ;  C1L254, COBS_LISMC ;  Q720T3, COBS_LISMF ;
DR   B8DC84, COBS_LISMH ;  Q8Y7X1, COBS_LISMO ;  A0AHP2, COBS_LISW6 ;
DR   Q8TS66, COBS_METAC ;  Q0W1P5, COBS_METAR ;  Q465W3, COBS_METBF ;
DR   Q12UB0, COBS_METBU ;  Q58833, COBS_METJA ;  Q8TUT2, COBS_METKA ;
DR   Q8PVB4, COBS_METMA ;  O27184, COBS_METTH ;  A0QEZ8, COBS_MYCA1 ;
DR   Q7VEN6, COBS_MYCBO ;  A1KKQ0, COBS_MYCBP ;  C1AQC3, COBS_MYCBT ;
DR   A4TBJ8, COBS_MYCGI ;  B2HGX7, COBS_MYCMM ;  Q73YK6, COBS_MYCPA ;
DR   A0R065, COBS_MYCS2 ;  A3Q1R8, COBS_MYCSJ ;  A1UIA4, COBS_MYCSK ;
DR   Q1B6S1, COBS_MYCSS ;  A5U4N6, COBS_MYCTA ;  P9WP90, COBS_MYCTO ;
DR   P9WP91, COBS_MYCTU ;  A0PTP3, COBS_MYCUA ;  A1TB16, COBS_MYCVP ;
DR   A1SJN0, COBS_NOCSJ ;  Q8YZS8, COBS_NOSS1 ;  Q2GBJ9, COBS_NOVAD ;
DR   B4SH93, COBS_PELPB ;  Q6L174, COBS_PICTO ;  A1VJY2, COBS_POLNA ;
DR   Q12FJ6, COBS_POLSJ ;  B4S891, COBS_PROA2 ;  A2CCL0, COBS_PROM3 ;
DR   Q7VDR6, COBS_PROMA ;  Q7V4T2, COBS_PROMM ;  Q48FK1, COBS_PSE14 ;
DR   Q15WS4, COBS_PSEA6 ;  A6V8S8, COBS_PSEA7 ;  Q02JC2, COBS_PSEAB ;
DR   Q9I463, COBS_PSEAE ;  Q1IDJ5, COBS_PSEE4 ;  Q4K8C3, COBS_PSEF5 ;
DR   C3K0Y6, COBS_PSEFS ;  A4XT57, COBS_PSEMY ;  A5W7Q2, COBS_PSEP1 ;
DR   Q3KFR3, COBS_PSEPF ;  B0KT69, COBS_PSEPG ;  Q88M93, COBS_PSEPK ;
DR   B1J1P0, COBS_PSEPW ;  Q885W4, COBS_PSESM ;  Q4ZQ68, COBS_PSEU2 ;
DR   Q9V2N1, COBS_PYRAB ;  Q8ZZ89, COBS_PYRAE ;  A3MWD7, COBS_PYRCJ ;
DR   Q8U400, COBS_PYRFU ;  O58111, COBS_PYRHO ;  A1RUA0, COBS_PYRIL ;
DR   Q8XWS4, COBS_RALN1 ;  B2UAJ1, COBS_RALPJ ;  B3PQS4, COBS_RHIE6 ;
DR   Q2K7G5, COBS_RHIEC ;  Q1MFK3, COBS_RHIJ3 ;  Q98KP0, COBS_RHILO ;
DR   B5ZSC5, COBS_RHILW ;  Q92P97, COBS_RHIME ;  B9JG16, COBS_RHIR8 ;
DR   A5V212, COBS_ROSS1 ;  Q97TZ6, COBS_SACS2 ;  A9MLS7, COBS_SALAR ;
DR   Q57MY0, COBS_SALCH ;  B5FLY5, COBS_SALDC ;  B5QYX4, COBS_SALEP ;
DR   B5RBK7, COBS_SALG2 ;  B4T8W9, COBS_SALHS ;  B4SWC6, COBS_SALNS ;
DR   Q5PDU1, COBS_SALPA ;  C0Q1Q9, COBS_SALPC ;  B5BG59, COBS_SALPK ;
DR   B4TZP6, COBS_SALSV ;  Q8Z5N8, COBS_SALTI ;  Q05602, COBS_SALTY ;
DR   A1S3L4, COBS_SHEAM ;  A3D7X7, COBS_SHEB5 ;  A6WJZ2, COBS_SHEB8 ;
DR   A9L3D9, COBS_SHEB9 ;  Q12Q70, COBS_SHEDO ;  Q086T5, COBS_SHEFN ;
DR   B0TSP8, COBS_SHEHH ;  Q8EI17, COBS_SHEON ;  A8H806, COBS_SHEPA ;
DR   A4Y9P2, COBS_SHEPC ;  B8CJ38, COBS_SHEPW ;  A0L0D2, COBS_SHESA ;
DR   Q0HLZ4, COBS_SHESM ;  Q0HRU2, COBS_SHESR ;  A1RGP2, COBS_SHESW ;
DR   B1KH27, COBS_SHEWM ;  B2TWQ9, COBS_SHIB3 ;  Q322B3, COBS_SHIBS ;
DR   Q32ED1, COBS_SHIDS ;  Q0T3C3, COBS_SHIF8 ;  Q83R13, COBS_SHIFL ;
DR   Q3Z0K3, COBS_SHISS ;  A6U9W5, COBS_SINMW ;  A4VJ44, COBS_STUS1 ;
DR   Q4JBK2, COBS_SULAC ;  C3N0R7, COBS_SULIA ;  C4KJU4, COBS_SULIK ;
DR   C3MJX7, COBS_SULIL ;  C3MRS8, COBS_SULIM ;  C3NMG6, COBS_SULIN ;
DR   C3N903, COBS_SULIY ;  Q96Y25, COBS_SULTO ;  Q8GMS2, COBS_SYNE7 ;
DR   A0LLI5, COBS_SYNFM ;  Q5N366, COBS_SYNP6 ;  Q55714, COBS_SYNY3 ;
DR   B7IHD7, COBS_THEAB ;  Q9HJ91, COBS_THEAC ;  C5A478, COBS_THEGJ ;
DR   Q52454, COBS_THEKO ;  A6LLB7, COBS_THEM4 ;  B6YV94, COBS_THEON ;
DR   B0KCS0, COBS_THEP3 ;  B0K2K2, COBS_THEPX ;  Q8DJ91, COBS_THEVB ;
DR   Q97BG1, COBS_THEVO ;  B5YL84, COBS_THEYD ;  Q3SFE7, COBS_THIDA ;
DR   Q73K39, COBS_TREDE ;  Q3M999, COBS_TRIV2 ;  A5F1U5, COBS_VIBC3 ;
DR   Q9KSL8, COBS_VIBCH ;  C3LLT4, COBS_VIBCM ;  Q87Q45, COBS_VIBPA ;
DR   Q8D922, COBS_VIBVU ;  Q7MLF2, COBS_VIBVY ;  A7IB66, COBS_XANP2 ;
DR   P29936, COBV_SINSX ;
//