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ENZYME entry: EC 2.7.8.27

Accepted Name
Sphingomyelin synthase.
Alternative Name(s)
Phosphatidylcholine:ceramide cholinephosphotransferase.
SM synthase.
Reaction catalysed
A ceramide + a phosphatidylcholine <=> a sphingomyelin + a 1,2-diacyl-sn-glycerol
Comment(s)
  • The reaction can occur in both directions.
  • Occupies a central position in sphingolipid and glycerophospholipid metabolism.
  • Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signaling in a variety of mammalian cell types.
  • Unlike EC 2.7.8.3 CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin.
Cross-references
BRENDA2.7.8.27
EC2PDB2.7.8.27
ExplorEnz2.7.8.27
PRIAM enzyme-specific profiles2.7.8.27
KEGG Ligand Database for Enzyme Nomenclature2.7.8.27
IUBMB Enzyme Nomenclature2.7.8.27
IntEnz2.7.8.27
MEDLINEFind literature relating to 2.7.8.27
MetaCyc2.7.8.27
Rhea expert-curated reactions2.7.8.27
UniProtKB/Swiss-Prot
Q38E55, SLS3_TRYB2;  B3A0M1, SLS3_TRYBB;  Q38E56, SLS4_TRYB2;  
B3A0M2, SLS4_TRYBB;  Q9U3D4, SMS1_CAEEL;  Q7T3T4, SMS1_CHICK;  
Q86VZ5, SMS1_HUMAN;  Q8VCQ6, SMS1_MOUSE;  A0AAS4, SMS1_PIG;  
Q7TSX5, SMS1_RAT;  Q20735, SMS2_CAEEL;  Q8NHU3, SMS2_HUMAN;  
Q4R763, SMS2_MACFA;  Q9D4B1, SMS2_MOUSE;  Q4JM44, SMS2_RAT;  
Q965Q4, SMS3_CAEEL;  

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