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ENZYME

ENZYME entry: EC 2.7.8.27

Accepted Name
sphingomyelin synthase
Alternative Name(s)
phosphatidylcholine:ceramide cholinephosphotransferase
SM synthase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + a sphingomyelin
Comment(s)
  • The reaction can occur in both directions.
  • Occupies a central position in sphingolipid and glycerophospholipid metabolism.
  • Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signaling in a variety of mammalian cell types.
  • Unlike EC 2.7.8.3 CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin.
Cross-references
BRENDA2.7.8.27
EC2PDB2.7.8.27
ExplorEnz2.7.8.27
PRIAM enzyme-specific profiles2.7.8.27
KEGG Ligand Database for Enzyme Nomenclature2.7.8.27
IUBMB Enzyme Nomenclature2.7.8.27
IntEnz2.7.8.27
MEDLINEFind literature relating to 2.7.8.27
MetaCyc2.7.8.27
Rhea expert-curated reactions2.7.8.27
UniProtKB/Swiss-Prot
B3A0L9, SLS1_TRYBBQ38E55, SLS3_TRYB2B3A0M1, SLS3_TRYBB
Q38E56, SLS4_TRYB2B3A0M2, SLS4_TRYBBQ9U3D4, SMS1_CAEEL
Q7T3T4, SMS1_CHICKQ86VZ5, SMS1_HUMANQ8VCQ6, SMS1_MOUSE
A0AAS4, SMS1_PIGQ7TSX5, SMS1_RATQ20735, SMS2_CAEEL
Q8NHU3, SMS2_HUMANQ4R763, SMS2_MACFAQ9D4B1, SMS2_MOUSE
Q4JM44, SMS2_RATQ965Q4, SMS3_CAEEL

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