ID   2.7.8.48
DE   ceramide phosphoethanolamine synthase.
AN   CPE synthase.
CA   (1) CDP-ethanolamine + an N-acyl-sphingoid base = an N-acyl-sphingoid
CA   1-phosphoethanolamine + CMP + H(+).
CA   (2) an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-
CA   phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine +
CA   a 1,2-diacyl-sn-glycerol.
CC   -!- The enzyme from invertebrates, best studied from the fly Drosophila
CC       melanogaster, is common in arthropods, worms, bees, spiders,
CC       and scorpions, and has also been reported in deep-sea mussels and
CC       some sea snails, as well as protozoans and oomycetes.
CC   -!- Its product, ceramide phosphoethanolamine, is synthesized as the main
CC       sphingolipid in cell membranes of arthropods, such as Drosophila and
CC       Musca.
CC   -!- The invertebrate enzyme requires a Mn(II) cofactor.
CC   -!- In mammals the activity has been shown to be catalyzed by members of
CC       the EC 2.7.8.27 family, such as SGMS1, SGMS2, and SAMD8.
CC   -!- Formerly EC 2.7.8.n3.
DR   O77475, CPESY_DROME;
//