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ENZYME entry: EC 2.7.9.6

Accepted Name
Rifampicin phosphotransferase.
Reaction catalysed
ATP + rifampicin + H(2)O <=> AMP + 21-phosphorifampicin + phosphate
Comment(s)
  • The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21.
  • The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate- carrying L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis.
Cross-references
BRENDA2.7.9.6
EC2PDB2.7.9.6
ExplorEnz2.7.9.6
PRIAM enzyme-specific profiles2.7.9.6
KEGG Ligand Database for Enzyme Nomenclature2.7.9.6
IUBMB Enzyme Nomenclature2.7.9.6
IntEnz2.7.9.6
MEDLINEFind literature relating to 2.7.9.6
MetaCyc2.7.9.6
Rhea expert-curated reactions2.7.9.6

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.9.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-