Home  |  Contact

ENZYME entry: EC 2.7.9.6

Accepted Name
Rifampicin phosphotransferase.
Reaction catalysed
ATP + rifampicin + H(2)O <=> AMP + 21-phosphorifampicin + phosphate
Comment(s)
  • The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21.
  • The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate- carrying L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis.
Cross-references
BRENDA2.7.9.6
EC2PDB2.7.9.6
ExplorEnz2.7.9.6
PRIAM enzyme-specific profiles2.7.9.6
KEGG Ligand Database for Enzyme Nomenclature2.7.9.6
IUBMB Enzyme Nomenclature2.7.9.6
IntEnz2.7.9.6
MEDLINEFind literature relating to 2.7.9.6
MetaCyc2.7.9.6

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.9.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-