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ENZYME

ENZYME entry: EC 2.8.1.7

Accepted Name
cysteine desulfurase
Alternative Name(s)
cysteine desulfurylase
Reaction catalysed
[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine
Comment(s)
  • The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors.
  • The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin).
  • In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation.
Cross-references
BRENDA2.8.1.7
EC2PDB2.8.1.7
ExplorEnz2.8.1.7
PRIAM enzyme-specific profiles2.8.1.7
KEGG Ligand Database for Enzyme Nomenclature2.8.1.7
IUBMB Enzyme Nomenclature2.8.1.7
IntEnz2.8.1.7
MEDLINEFind literature relating to 2.8.1.7
MetaCyc2.8.1.7
Rhea expert-curated reactions2.8.1.7
UniProtKB/Swiss-Prot
Q93WX6, CNIF1_ARATHQ49690, CSD2_MYCLEQ46925, CSDA_ECOLI
Q9YAB6, CSD_AERPEO51111, CSD_BORBUQ9PLP0, CSD_CHLMU
Q9Z7L5, CSD_CHLPNO84693, CSD_CHLTRQ57476, CSD_HAEIN
Q9K7A0, CSD_HALH5Q9HMM6, CSD_HALSAO27442, CSD_METTH
P63517, CSD_MYCBOQ49420, CSD_MYCGEP75298, CSD_MYCPN
P9WQ68, CSD_MYCTOP9WQ69, CSD_MYCTUP57989, CSD_PASMU
Q9HXX3, CSD_PSEAEQ9Z408, CSD_PSEPKQ9V242, CSD_PYRAB
Q5HHH0, CSD_STAACP63518, CSD_STAAMP99177, CSD_STAAN
Q6GIH2, CSD_STAARQ6GB11, CSD_STAASQ8NXH0, CSD_STAAW
Q5HQQ0, CSD_STAEQQ8CTA4, CSD_STAESQ9XAD5, CSD_STRCO
Q55793, CSD_SYNY3Q9X191, CSD_THEMAO83623, CSD_TREPA
Q9PQ36, CSD_UREPAQ9KPQ7, CSD_VIBCHQ9PDA6, CSD_XYLFA
Q87DJ2, CSD_XYLFTO32975, CYD_MYCLEQ9KII6, CYD_MYCPA
Q8KUU5, CYD_SYNE7O30052, ISCS1_ARCFUO34599, ISCS1_BACSU
O29689, ISCS2_ARCFUO34874, ISCS2_BACSUP9WQ70, ISCSL_MYCTO
P9WQ71, ISCSL_MYCTUB7H3H0, ISCS_ACIB3B7I5Q3, ISCS_ACIB5
B2HZI5, ISCS_ACIBCB0VNW2, ISCS_ACIBSB0VD51, ISCS_ACIBY
A6VMN7, ISCS_ACTSZA0KJ32, ISCS_AERHHA4SP14, ISCS_AERS4
B8JC53, ISCS_ANAD2Q2INI7, ISCS_ANADEA7H804, ISCS_ANADF
B4UCP2, ISCS_ANASKC1DE68, ISCS_AZOVDO31269, ISCS_AZOVI
B8D8F9, ISCS_BUCA5P57657, ISCS_BUCAIO51886, ISCS_BUCAP
B8D8B6, ISCS_BUCATQ89A19, ISCS_BUCBPA7FWJ9, ISCS_CLOB1
A5I4Z9, ISCS_CLOBHC1FTC4, ISCS_CLOBJQ486Z0, ISCS_COLP3
A7MGX8, ISCS_CROS8Q47EN5, ISCS_DECARB8DZS1, ISCS_DICTD
A7ZPX4, ISCS_ECO24B7UGX6, ISCS_ECO27B7MIM0, ISCS_ECO45
B7LDC2, ISCS_ECO55P0A6B9, ISCS_ECO57B5Z104, ISCS_ECO5E
B7NRH9, ISCS_ECO7IB7MYG3, ISCS_ECO81B7M7N3, ISCS_ECO8A
C4ZXA5, ISCS_ECOBWB1XB05, ISCS_ECODHA8A336, ISCS_ECOHS
Q0TEV5, ISCS_ECOL5P0A6B8, ISCS_ECOL6B1IWD1, ISCS_ECOLC
P0A6B7, ISCS_ECOLIB7N6B7, ISCS_ECOLUB6I5A2, ISCS_ECOSE
B1LNI6, ISCS_ECOSMC5BEU5, ISCS_EDWI9Q2GGJ4, ISCS_EHRCR
A4WDB1, ISCS_ENT38B2VI32, ISCS_ERWT9B7LKA9, ISCS_ESCF3
B8F356, ISCS_GLAP5Q7VMA9, ISCS_HAEDUA5UAA8, ISCS_HAEIE
A5UGI1, ISCS_HAEIGQ57337, ISCS_HAEINQ0I1L2, ISCS_HAES1
B6JKF2, ISCS_HELP2Q9ZML2, ISCS_HELPJB2US50, ISCS_HELPS
O25008, ISCS_HELPYB0UVL5, ISCS_HISS2B5XNJ7, ISCS_KLEP3
A6TCF1, ISCS_KLEP7Q65RS7, ISCS_MANSMQ60C64, ISCS_METCA
Q1H361, ISCS_METFKP57795, ISCS_METTEQ5F8X4, ISCS_NEIG1
B4RMB8, ISCS_NEIG2A9M029, ISCS_NEIM0Q9JTX0, ISCS_NEIMA
Q9JYY0, ISCS_NEIMBA1KUK1, ISCS_NEIMFP57803, ISCS_PASMU
Q6D259, ISCS_PECASC6DBJ1, ISCS_PECCPQ7N224, ISCS_PHOLL
Q6LU62, ISCS_PHOPRB4EZU8, ISCS_PROMHQ48M05, ISCS_PSE14
A6V0U8, ISCS_PSEA7B7UWH7, ISCS_PSEA8Q02RW8, ISCS_PSEAB
Q9HXI8, ISCS_PSEAEQ1IEJ2, ISCS_PSEE4Q4K6T8, ISCS_PSEF5
C3K1M5, ISCS_PSEFSA4XY43, ISCS_PSEMYA5VYS4, ISCS_PSEP1
Q3K7A5, ISCS_PSEPFB0KPH6, ISCS_PSEPGQ88PK8, ISCS_PSEPK
B1JDR3, ISCS_PSEPWQ887A1, ISCS_PSESMQ3IFI3, ISCS_PSET1
Q4ZX34, ISCS_PSEU2A4VNY2, ISCS_PSEU5A1SUI4, ISCS_PSYIN
C3PNQ8, ISCS_RICAEA8GNU0, ISCS_RICAHA8GWB2, ISCS_RICB8
Q1RHY6, ISCS_RICBRA8EYH9, ISCS_RICCKQ92HP1, ISCS_RICCN
Q4UL77, ISCS_RICFEA8F204, ISCS_RICM5Q9ZD60, ISCS_RICPR
C4K1Z7, ISCS_RICPUB0BXX6, ISCS_RICROA8GSG4, ISCS_RICRS
Q68WP6, ISCS_RICTYO54055, ISCS_RUMFLA1AWM1, ISCS_RUTMC
B5F1C0, ISCS_SALA4A9MHJ4, ISCS_SALARQ57LG9, ISCS_SALCH
B5FR85, ISCS_SALDCB5R5A2, ISCS_SALEPB5RD12, ISCS_SALG2
B4TDB6, ISCS_SALHSB4T0S2, ISCS_SALNSQ5PNG1, ISCS_SALPA
A9N1X5, ISCS_SALPBC0PYK7, ISCS_SALPCB5BAW6, ISCS_SALPK
B4TRX5, ISCS_SALSVQ8Z4N0, ISCS_SALTIQ8ZN40, ISCS_SALTY
A8GHY3, ISCS_SERP5A1S544, ISCS_SHEAMB8E9D2, ISCS_SHEB2
A3D577, ISCS_SHEB5A6WNY5, ISCS_SHEB8A9L3R0, ISCS_SHEB9
Q12P83, ISCS_SHEDOQ080P6, ISCS_SHEFNB0TNY1, ISCS_SHEHH
A3QFD5, ISCS_SHELPQ8EEU9, ISCS_SHEONA8H2M6, ISCS_SHEPA
A4Y7D7, ISCS_SHEPCB8CMW5, ISCS_SHEPWA0KXJ0, ISCS_SHESA
A8FXA5, ISCS_SHESHQ0HJF4, ISCS_SHESMQ0HVP4, ISCS_SHESR
A1RJ52, ISCS_SHESWB1KNI3, ISCS_SHEWMB2TXV5, ISCS_SHIB3
Q0T1Y9, ISCS_SHIF8P0A6C0, ISCS_SHIFLC4L7K2, ISCS_TOLAT
A5CWM6, ISCS_VESOHB7VJS6, ISCS_VIBA3A7MU48, ISCS_VIBC1
A5F3G4, ISCS_VIBC3Q9KTY2, ISCS_VIBCHC3LT01, ISCS_VIBCM
Q87S28, ISCS_VIBPAQ8DEY7, ISCS_VIBVUQ7MNG2, ISCS_VIBVY
O49543, MNIF1_ARATHP0DN31, NFS1_ARTBCO60028, NFS1_ASHGO
P87185, NFS1_CANALP87187, NFS1_CANMAQ54X04, NFS1_DICDI
Q9VKD3, NFS1_DROMEQ8SQS2, NFS1_ENCCUQ9Y697, NFS1_HUMAN
Q9Z1J3, NFS1_MOUSEQ5RDE7, NFS1_PONABQ99P39, NFS1_RAT
O74351, NFS1_SCHPOB0YLW6, NFS1_TRAHOP25374, NFS1_YEAST
Q44507, NIFS1_TRIV2Q44482, NIFS2_TRIV2P70727, NIFS_AZOBR
P23120, NIFS_AZOCHP05341, NIFS_AZOVIP38033, NIFS_BACSU
P37030, NIFS_BRADUQ01179, NIFS_CERSPQ52069, NIFS_ENTAG
Q9Z5X5, NIFS_FRASEP57794, NIFS_GLUDAQ9KDJ6, NIFS_HALH5
P05344, NIFS_KLEPNP12623, NIFS_NOSS1Q07177, NIFS_RHOCA
P55690, NIFS_SINFNQ43884, NIFS_TRIAZO32164, SUFS_BACSU
A8AH80, SUFS_CITK8A7MF59, SUFS_CROS8Q9EXP2, SUFS_DICD3
A7ZME5, SUFS_ECO24B7US19, SUFS_ECO27B7MA32, SUFS_ECO45
B7L5N2, SUFS_ECO55Q7ADI4, SUFS_ECO57B5Z4B3, SUFS_ECO5E
B7NTV6, SUFS_ECO7IB7MV59, SUFS_ECO81B7M0N5, SUFS_ECO8A
C4ZYE2, SUFS_ECOBWB1XFY8, SUFS_ECODHA8A0M6, SUFS_ECOHS
A1ABL8, SUFS_ECOK1Q0THE9, SUFS_ECOL5Q8FH54, SUFS_ECOL6
B1IQ76, SUFS_ECOLCP77444, SUFS_ECOLIB7N516, SUFS_ECOLU
B6IBB9, SUFS_ECOSEB1LE56, SUFS_ECOSMQ1RBB6, SUFS_ECOUT
A4W9R3, SUFS_ENT38B7LQ96, SUFS_ESCF3D4GYV5, SUFS_HALVD
B5XQH2, SUFS_KLEP3A6TAE4, SUFS_KLEP7Q6D625, SUFS_PECAS
C6DKM6, SUFS_PECCPQ7N3U5, SUFS_PHOLLB5F7C4, SUFS_SALA4
A9MEP3, SUFS_SALARQ57PR2, SUFS_SALCHB5FIM3, SUFS_SALDC
B5QVS9, SUFS_SALEPB5RAT4, SUFS_SALG2B4TGK9, SUFS_SALHS
B4T4R6, SUFS_SALNSA9N142, SUFS_SALPBB4TUT5, SUFS_SALSV
Q8XF77, SUFS_SALTIQ7CQN5, SUFS_SALTYA8GDU4, SUFS_SERP5
B2U2I4, SUFS_SHIB3Q321D9, SUFS_SHIBSQ7UAH4, SUFS_SHIFL
Q3Z233, SUFS_SHISSQ8D2J7, SUFS_WIGBRA7FHJ2, SUFS_YERP3
Q1C761, SUFS_YERPAB2K5J4, SUFS_YERPBQ8D0M6, SUFS_YERPE
A9QZC9, SUFS_YERPGQ1CIJ6, SUFS_YERPNA4TIP2, SUFS_YERPP
Q66A22, SUFS_YERPSB1JJ48, SUFS_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-