ID   2.8.2.14
DE   bile-salt sulfotransferase.
AN   BAST I.
AN   bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase.
AN   bile acid sulfotransferase I.
AN   bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase.
AN   glycolithocholate sulfotransferase.
CA   (1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine
CA   3',5'-bisphosphate + H(+) + sulfoglycolithocholate.
CA   (2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine
CA   3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate.
CC   -!- The formation of sulfate esters of bile acids is an essential step in
CC       the prevention of toxicity by monohydroxy bile acids in many species.
CC   -!- This enzyme is both a bile salt and a 3-hydroxysteroid
CC       sulfotransferase.
CC   -!- In addition to the 5beta-bile acid glycolithocholate, deoxycholate,
CC       3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-
CC       hydroxyandrost-5-en-17-one) also act as substrates (see also
CC       EC 2.8.2.2 and EC 2.8.2.34).
CC   -!- May be identical to EC 2.8.2.2.
DR   Q06520, ST2A1_HUMAN;  P52842, ST2A1_MACFA;  P52843, ST2A1_MOUSE;
DR   P15709, ST2A1_RAT  ;  B2RVI8, ST2A6_MOUSE;  P22789, ST2A6_RAT  ;
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