ENZYME entry: EC 2.8.2.23
Accepted Name |
[Heparan sulfate]-glucosamine 3-sulfotransferase 1.
|
Alternative Name(s) |
3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase. |
3-OST-1. |
Glucosaminyl 3-O-sulfotransferase. |
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase. |
Heparin-glucosamine 3-O-sulfotransferase. |
Reaction catalysed |
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine <=> adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate |
Comment(s) |
- This enzyme differs from EC 2.8.2.29 and EC 2.8.2.30 by being the
most selective for a precursor of the antithrombin-binding site.
- It has a minimal acceptor sequence of: -> GlcNAc6S->GlcA->
GlcN2S*+-6S->IdoA2S->GlcN2S->.
- It can also modify other precursor sequences within heparan sulfate
but this action does not create functional antithrombin-binding
sites.
- These precursors are variants of the consensus sequence: ->
Glc(N2S>NAc)+-6S->GlcA->GlcN2S*+-6S->GlcA>IdoA+-2S->
Glc(N2S/NAc)+-6S->.
- If the heparan sulfate substrate lacks 2-O-sulfation of GlcA
residues, then enzyme specificity is expanded to modify selected
glucosamine residues preceded by IdoA as well as GlcA.
|
Cross-references |
BRENDA | 2.8.2.23 |
EC2PDB | 2.8.2.23 |
ExplorEnz | 2.8.2.23 |
PRIAM enzyme-specific profiles | 2.8.2.23 |
KEGG Ligand Database for Enzyme Nomenclature | 2.8.2.23 |
IUBMB Enzyme Nomenclature | 2.8.2.23 |
IntEnz | 2.8.2.23 |
MEDLINE | Find literature relating to 2.8.2.23 |
MetaCyc | 2.8.2.23 |
UniProtKB/Swiss-Prot |
|
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