ID 2.8.2.29 DE [heparan sulfate]-glucosamine 3-sulfotransferase 2. AN 3-OST-2. AN glucosaminyl 3-O-sulfotransferase 2. AN heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2. CA 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = CA 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine CA 3',5'-bisphosphate + H(+). CC -!- This enzyme sulfates the residues marked with an asterisk in CC sequences containing at least ->IdoA2S->GlcN*-> or ->GlcA2S->GlcN*->. CC -!- Preference for GlcN2S versus unmodified GlcN has not yet been CC established. CC -!- Additional structural features are presumably required for substrate CC recognition, since the 3-O-sulfated residue is of low abundance, CC whereas the above IdoA-containing sequence is quite abundant. CC -!- This enzyme differs from the other [heparan sulfate]-glucosamine CC 3-sulfotransferases by modifying selected glucosamine residues CC preceded by GlcA2S; EC 2.8.2.23 prefers GlcA or IdoA, whereas CC EC 2.8.2.30 prefers IdoA2S. DR Q9Y278, HS3S2_HUMAN; Q673U1, HS3S2_MOUSE; Q80W66, HS3S2_RAT ; //