ID   2.8.2.29
DE   [heparan sulfate]-glucosamine 3-sulfotransferase 2.
AN   3-OST-2.
AN   glucosaminyl 3-O-sulfotransferase 2.
AN   heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2.
CA   3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) =
CA   3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine
CA   3',5'-bisphosphate + H(+).
CC   -!- This enzyme sulfates the residues marked with an asterisk in
CC       sequences containing at least ->IdoA2S->GlcN*-> or ->GlcA2S->GlcN*->.
CC   -!- Preference for GlcN2S versus unmodified GlcN has not yet been
CC       established.
CC   -!- Additional structural features are presumably required for substrate
CC       recognition, since the 3-O-sulfated residue is of low abundance,
CC       whereas the above IdoA-containing sequence is quite abundant.
CC   -!- This enzyme differs from the other [heparan sulfate]-glucosamine
CC       3-sulfotransferases by modifying selected glucosamine residues
CC       preceded by GlcA2S; EC 2.8.2.23 prefers GlcA or IdoA, whereas
CC       EC 2.8.2.30 prefers IdoA2S.
DR   Q9Y278, HS3S2_HUMAN;  Q673U1, HS3S2_MOUSE;  Q80W66, HS3S2_RAT  ;
//