ID 2.8.2.30 DE [heparan sulfate]-glucosamine 3-sulfotransferase 3. AN 3-OST-3. AN glucosaminyl 3-O-sulfotransferase 3. AN heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3. CA 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = CA 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine CA 3',5'-bisphosphate + H(+). CC -!- Two major substrates contain the tetrasaccharides: -> undetermined CC 2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN*-> and -> undetermined CC 2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN6S*-> with modification of CC the N-unsubstituted glucosamine residue (shown with an asterisk). CC -!- Modification of selected sequences containing N-sulfo-glucosamine CC residues cannot yet be excluded. CC -!- The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex CC virus type 1 as an entry receptor to infect the target cells. CC -!- There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have CC identical catalytic domains but are encoded by different mammalian CC genes. CC -!- The specificity of this enzyme differs from that of the other CC [heparan sulfate]-glucosamine 3-sulfotransferases. CC -!- It is inefficient at modifying precursors of the antithrombin binding CC site (in contrast to EC 2.8.2.23) and it does not modify glucosamine CC preceded by GlcA2S (unlike EC 2.8.2.29). DR Q9Y663, HS3SA_HUMAN; Q9Y662, HS3SB_HUMAN; Q9QZS6, HS3SB_MOUSE; //