ENZYME entry: EC 2.8.2.35
Accepted Name |
Dermatan 4-sulfotransferase.
|
Alternative Name(s) |
CHST14 protein. |
Dermatan N-acetylgalactosamine 4-O-sulfotransferase. |
Dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. |
Reaction catalysed |
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine <=> adenosine 3',5'-bisphosphate + [dermatan]- 4-O-sulfo-N-acetyl-D-galactosamine |
Comment(s) |
- The sulfation takes place at the 4-position of N-acetylgalactosamine
residues of dermatan.
- D4ST-1 shows a strong preference in vitro for sulfate transfer to
IdoUA-alpha(1,3)GalNAc-beta(1,4) that is flanked by GlcUA-
beta(1,3)GalNAc-beta(1,4) as compared with IdoUA-alpha(1,3)GalNAc-
beta(1,4) flanked by IdoUA-alpha(1,3)GalNAc-beta(1,4).
|
Cross-references |
BRENDA | 2.8.2.35 |
EC2PDB | 2.8.2.35 |
ExplorEnz | 2.8.2.35 |
PRIAM enzyme-specific profiles | 2.8.2.35 |
KEGG Ligand Database for Enzyme Nomenclature | 2.8.2.35 |
IUBMB Enzyme Nomenclature | 2.8.2.35 |
IntEnz | 2.8.2.35 |
MEDLINE | Find literature relating to 2.8.2.35 |
MetaCyc | 2.8.2.35 |
UniProtKB/Swiss-Prot |
|
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