ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.8.2.35

Accepted Name

Dermatan 4-sulfotransferase.

Alternative Name(s)

CHST14 protein.

Dermatan N-acetylgalactosamine 4-O-sulfotransferase.

Dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.

Reaction catalysed

3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine <=> adenosine 3',5'-bisphosphate + [dermatan]- 4-O-sulfo-N-acetyl-D-galactosamine

Comment(s)

The sulfation takes place at the 4-position of N-acetylgalactosamine residues of dermatan.
D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUA-alpha(1,3)GalNAc-beta(1,4) that is flanked by GlcUA- beta(1,3)GalNAc-beta(1,4) as compared with IdoUA-alpha(1,3)GalNAc- beta(1,4) flanked by IdoUA-alpha(1,3)GalNAc-beta(1,4).

Cross-references

BRENDA

2.8.2.35

EC2PDB

2.8.2.35

ExplorEnz

2.8.2.35

PRIAM enzyme-specific profiles

2.8.2.35

KEGG Ligand Database for Enzyme Nomenclature

2.8.2.35

IUBMB Enzyme Nomenclature