ENZYME entry: EC 2.8.2.35
| Accepted Name |
|---|
| Dermatan 4-sulfotransferase.
|
| Alternative Name(s) |
|---|
| CHST14 protein. |
| Dermatan N-acetylgalactosamine 4-O-sulfotransferase. |
| Dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. |
| Reaction catalysed |
|---|
| 3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine <=> adenosine 3',5'-bisphosphate + [dermatan]- 4-O-sulfo-N-acetyl-D-galactosamine |
| Comment(s) |
|---|
- The sulfation takes place at the 4-position of N-acetylgalactosamine
residues of dermatan.
- D4ST-1 shows a strong preference in vitro for sulfate transfer to
IdoUA-alpha(1,3)GalNAc-beta(1,4) that is flanked by GlcUA-
beta(1,3)GalNAc-beta(1,4) as compared with IdoUA-alpha(1,3)GalNAc-
beta(1,4) flanked by IdoUA-alpha(1,3)GalNAc-beta(1,4).
|
| Cross-references |
|---|
| BRENDA | 2.8.2.35 |
| EC2PDB | 2.8.2.35 |
| ExplorEnz | 2.8.2.35 |
| PRIAM enzyme-specific profiles | 2.8.2.35 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.8.2.35 |
| IUBMB Enzyme Nomenclature | 2.8.2.35 |
| IntEnz | 2.8.2.35 |
| MEDLINE | Find literature relating to 2.8.2.35 |
| MetaCyc | 2.8.2.35 |
| Rhea expert-curated reactions | 2.8.2.35 |
| UniProtKB/Swiss-Prot |
|
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