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ENZYME

ENZYME entry: EC 2.8.2.8

PURL: https://purl.expasy.org/enzyme/EC/2.8.2.8
Accepted Name
[heparan sulfate]-glucosamine N-sulfotransferase
Alternative Name(s)
3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase
3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase
3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase
desulfoheparin sulfotransferase
glucosaminyl N-deacetylase/N-sulfotransferase
heparan sulfate 2-N-sulfotransferase
heparan sulfate N-deacetylase/N-sulfotransferase
heparan sulfate N-sulfotransferase
heparan sulfate sulfotransferase
heparin N-sulfotransferase
heparitin sulfotransferase
N-desulfoheparin sulfotransferase
N-heparan sulfate sulfotransferase
N-HSST
PAPS:DSH sulfotransferase
PAPS:N-desulfoheparin sulfotransferase
Reaction catalysed
alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + 2 H(+)
Comment(s)
  • The enzyme also catalyzes the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.
  • Formerly EC 2.8.2.12.
Cross-references
BRENDA2.8.2.8
EC2PDB2.8.2.8
ExplorEnz2.8.2.8
KEGG Ligand Database for Enzyme Nomenclature2.8.2.8
IUBMB Enzyme Nomenclature2.8.2.8
MEDLINEFind literature relating to 2.8.2.8
MetaCyc2.8.2.8
Rhea expert-curated reactions2.8.2.8
UniProtKB/Swiss-Prot
P52848, NDST1_HUMANQ3UHN9, NDST1_MOUSEQ02353, NDST1_RAT
Q6GQK9, NDST1_XENLAQ5U4X8, NDST1_XENTRO97583, NDST2_BOVIN
P52849, NDST2_HUMANP52850, NDST2_MOUSEO95803, NDST3_HUMAN
Q9EQH7, NDST3_MOUSEQ9H3R1, NDST4_HUMANQ9EQW8, NDST4_MOUSE
Q60V90, NDST_CAEBRQ966W3, NDST_CAEELQ9V3L1, NDST_DROME

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-