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ENZYME entry: EC 2.8.3.24

Accepted Name
(R)-2-hydroxy-4-methylpentanoate CoA-transferase.
Reaction catalysed
4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate <=> 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
Comment(s)
  • The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway.
  • The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.
Cross-references
BRENDA2.8.3.24
EC2PDB2.8.3.24
ExplorEnz2.8.3.24
PRIAM enzyme-specific profiles2.8.3.24
KEGG Ligand Database for Enzyme Nomenclature2.8.3.24
IUBMB Enzyme Nomenclature2.8.3.24
IntEnz2.8.3.24
MEDLINEFind literature relating to 2.8.3.24
MetaCyc2.8.3.24

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-