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ENZYME

ENZYME entry: EC 2.8.3.24

PURL: https://purl.expasy.org/enzyme/EC/2.8.3.24
Accepted Name
(R)-2-hydroxy-4-methylpentanoate CoA-transferase
Reaction catalysed
4-methylpentanoyl-CoA + (2R)-hydroxy-4-methylpentanoate = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate
Comment(s)
  • The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway.
  • The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.
Cross-references
BRENDA2.8.3.24
EC2PDB2.8.3.24
ExplorEnz2.8.3.24
KEGG Ligand Database for Enzyme Nomenclature2.8.3.24
IUBMB Enzyme Nomenclature2.8.3.24
MEDLINEFind literature relating to 2.8.3.24
MetaCyc2.8.3.24
Rhea expert-curated reactions2.8.3.24
UniProtKB/Swiss-Prot
Q5U921, HADA_CLODI

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