ID 2.8.3.25 DE Bile acid CoA-transferase. AN Bile acid coenzyme A transferase. CA (1) Lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA. CA (2) Deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA. CC -!- The enzyme, characterized from the gut bacterium Clostridium CC scindens, catalyzes the last step in bile acid 7-alpha- CC dehydroxylation, the removal of the CoA moiety from the products. CC -!- By using a transferase rather than hydrolase, the bacteria conserve CC the thioester bond energy, saving ATP molecules. CC -!- The enzyme has a broad substrate specificity and can use multiple CC acceptors, including allocholate, ursodeoxycholate, and beta- CC muricholate. CC -!- Formerly EC 3.1.2.26. DR P19413, BAIF_CLOSV ; //