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ENZYME entry: EC 2.8.3.8

Accepted Name
acetate CoA-transferase.
Reaction catalysed
acetate + an acyl-CoA <=> a carboxylate + acetyl-CoA
Comment(s)
  • The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism.
  • The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue.
  • Unlike EC 2.8.3.9, this enzyme exhibits maximal activity using acetate as the CoA acceptor.
  • Substrate range depends on the specific enzyme.
  • Typical substrates include butanoyl-CoA and pentanoyl-CoA.
Cross-references
BRENDA2.8.3.8
EC2PDB2.8.3.8
ExplorEnz2.8.3.8
PRIAM enzyme-specific profiles2.8.3.8
KEGG Ligand Database for Enzyme Nomenclature2.8.3.8
IUBMB Enzyme Nomenclature2.8.3.8
IntEnz2.8.3.8
MEDLINEFind literature relating to 2.8.3.8
MetaCyc2.8.3.8
Rhea expert-curated reactions2.8.3.8
UniProtKB/Swiss-Prot
P76459, ATOA_ECOLI;  P44874, ATOA_HAEIN;  P76458, ATOD_ECOLI;  
P44875, ATOD_HAEIN;  Q8X5X6, YDIF_ECO57;  P37766, YDIF_ECOLI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
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