ID   2.8.4.1
DE   coenzyme-B sulfoethylthiotransferase.
AN   methyl coenzyme M reductase.
AN   methyl-CoM reductase.
CA   coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide +
CA   methane.
CC   -!- This enzyme catalyzes the final step in methanogenesis,
CC       the biological production of methane.
CC   -!- This important anaerobic process is carried out only by methanogenic
CC       archaea.
CC   -!- The enzyme can also function in reverse, for anaerobic oxidation of
CC       methane.
CC   -!- The enzyme requires the hydroporphinoid nickel complex coenzyme F430.
CC   -!- Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and
CC       difluoromethyl CoM are poor substrates.
CC   -!- The sulfide sulfur can be replaced by selenium but not by oxygen.
DR   Q8THH1, MCRA_METAC ;  P07962, MCRA_METBF ;  P12971, MCRA_METFE ;
DR   Q58256, MCRA_METJA ;  Q49605, MCRA_METKA ;  P22948, MCRA_METTE ;
DR   O27232, MCRA_METTH ;  P11558, MCRA_METTM ;  P07961, MCRA_METVA ;
DR   P11559, MCRA_METVO ;  P07955, MCRB_METBF ;  P12972, MCRB_METFE ;
DR   Q58252, MCRB_METJA ;  P22949, MCRB_METTE ;  O27236, MCRB_METTH ;
DR   P11560, MCRB_METTM ;  P07956, MCRB_METVA ;  P11561, MCRB_METVO ;
DR   P07964, MCRG_METBF ;  P12973, MCRG_METFE ;  Q58255, MCRG_METJA ;
DR   P22950, MCRG_METTE ;  O27233, MCRG_METTH ;  P11562, MCRG_METTM ;
DR   P07963, MCRG_METVA ;  P11563, MCRG_METVO ;  Q49174, MCRX_METFV ;
DR   Q60391, MCRX_METJA ;  P21110, MCRX_METTH ;  P58815, MCRX_METTM ;
DR   Q49171, MCRY_METFV ;  Q60390, MCRY_METJA ;  P21111, MCRY_METTH ;
DR   D9PXZ6, MCRY_METTM ;  Q49173, MCRZ_METFV ;  Q60387, MCRZ_METJA ;
DR   P21112, MCRZ_METTH ;  P58816, MCRZ_METTM ;
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