ENZYME entry: EC 2.8.4.5
Accepted Name |
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase.
|
Alternative Name(s) |
methylthio-threonylcarbamoyl-adenosine transferase B. |
Reaction catalysed |
[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine |
Comment(s) |
- The enzyme, which is a member of the S-adenosyl-L-methionine-
dependent radical (radical AdoMet) enzymes superfamily, binds two
[4Fe-4S] clusters as well as the transferred sulfur.
- The sulfur donor is believed to be one of the [4Fe-4S] clusters,
which is sacrificed in the process, so that in vitro the reaction is
a single turnover.
- The identity of the electron donor is not known.
|
Cross-references |
BRENDA | 2.8.4.5 |
EC2PDB | 2.8.4.5 |
ExplorEnz | 2.8.4.5 |
PRIAM enzyme-specific profiles | 2.8.4.5 |
KEGG Ligand Database for Enzyme Nomenclature | 2.8.4.5 |
IUBMB Enzyme Nomenclature | 2.8.4.5 |
IntEnz | 2.8.4.5 |
MEDLINE | Find literature relating to 2.8.4.5 |
MetaCyc | 2.8.4.5 |
Rhea expert-curated reactions | 2.8.4.5 |
UniProtKB/Swiss-Prot |
O29021, AMTAB_ARCFU; | Q58277, AMTAB_METJA; | O26914, AMTAB_METTH; |
Q9UXX9, AMTAB_PYRAB; | O59545, AMTAB_PYRHO; | Q8MXQ7, CDKAL_CAEEL; |
Q6PG34, CDKAL_DANRE; | Q7K4W1, CDKAL_DROME; | Q291H5, CDKAL_DROPS; |
Q5VV42, CDKAL_HUMAN; | Q91WE6, CDKAL_MOUSE; | Q6NS26, CDKAL_XENLA; |
Q6P4Y0, CDKAL_XENTR; | O66772, MTAB_AQUAE; | P54462, MTAB_BACSU; |
Q9Z874, MTAB_CHLPN; | Q49573, MTAB_MALIO; | Q9ZDB6, MTAB_RICPR; |
Q9WZT7, MTAB_THEMA; | O83293, MTAB_TREPA; |
|
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UniProtKB/Swiss-Prot entries corresponding to 2.8.4.-
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