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ENZYME entry: EC 2.9.1.3

Accepted Name
tRNA 2-selenouridine synthase.
Reaction catalysed
Selenophosphate + geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(2)O <=> 5-methylaminomethyl-2-selenouridine(34) in tRNA + (2E)-3,7-dimethylocta-2,6-diene-1-thiol + diphosphate + phosphate
Comment(s)
  • This bacterial enzyme converts 5-methylaminomethyl-2-uridine and 5-carboxymethylaminomethyl-2-uridine to the respective selenouridine forms in a two-step process that involves geranylation and subsequent phosphoselenation of the resulting geranylated intermediates.
  • The resultant seleno-phosphorylated uridine intermediates further react with a water molecule to release a phosphate anion and 2-selenouridine tRNA.
  • The enzyme contains a rhodanese domain.
Cross-references
BRENDA2.9.1.3
EC2PDB2.9.1.3
ExplorEnz2.9.1.3
PRIAM enzyme-specific profiles2.9.1.3
KEGG Ligand Database for Enzyme Nomenclature2.9.1.3
IUBMB Enzyme Nomenclature2.9.1.3
IntEnz2.9.1.3
MEDLINEFind literature relating to 2.9.1.3
MetaCyc2.9.1.3
Rhea expert-curated reactions2.9.1.3
UniProtKB/Swiss-Prot
A0KKE6, SELU_AERHH;  A4SMM2, SELU_AERS4;  Q0VNT0, SELU_ALCBS;  
C1DNN5, SELU_AZOVD;  Q6MK43, SELU_BDEBA;  Q7WE96, SELU_BORBR;  
A9I3Z9, SELU_BORPD;  Q1R084, SELU_CHRSD;  Q488J6, SELU_COLP3;  
A7MJZ3, SELU_CROS8;  Q0KEU1, SELU_CUPNH;  Q476K0, SELU_CUPPJ;  
B2AGP0, SELU_CUPTR;  A7ZIR0, SELU_ECO24;  B7UKI1, SELU_ECO27;  
B7ME26, SELU_ECO45;  B7L7D0, SELU_ECO55;  Q8XCZ2, SELU_ECO57;  
B5YPM0, SELU_ECO5E;  B7MQL5, SELU_ECO81;  B7M4K7, SELU_ECO8A;  
C4ZUV3, SELU_ECOBW;  B1XFT8, SELU_ECODH;  A7ZXF7, SELU_ECOHS;  
A1A8G9, SELU_ECOK1;  Q0TKD8, SELU_ECOL5;  Q8FK67, SELU_ECOL6;  
B1IZ97, SELU_ECOLC;  P33667, SELU_ECOLI;  B7N958, SELU_ECOLU;  
B6I0F4, SELU_ECOSE;  B1LKC2, SELU_ECOSM;  Q1RF31, SELU_ECOUT;  
B7LJH5, SELU_ESCF3;  Q2SQB9, SELU_HAHCH;  Q31GV5, SELU_HYDCU;  
A1U6R9, SELU_MARHV;  Q0AFI5, SELU_NITEC;  Q82WE9, SELU_NITEU;  
Q6LP06, SELU_PHOPR;  B4F2U3, SELU_PROMH;  Q48NL9, SELU_PSE14;  
A6V7E9, SELU_PSEA7;  B7UV78, SELU_PSEA8;  Q02KC8, SELU_PSEAB;  
Q9I382, SELU_PSEAE;  Q1IEL0, SELU_PSEE4;  Q4KEE7, SELU_PSEF5;  
A4XV44, SELU_PSEMY;  A5VYQ1, SELU_PSEP1;  Q3K9R2, SELU_PSEPF;  
B0KPF4, SELU_PSEPG;  Q88PM7, SELU_PSEPK;  B1JDU1, SELU_PSEPW;  
Q889F6, SELU_PSESM;  Q4ZYK5, SELU_PSEU2;  A1SRN6, SELU_PSYIN;  
B5EYB4, SELU_SALA4;  A9MLB3, SELU_SALAR;  Q57S51, SELU_SALCH;  
B5FLM4, SELU_SALDC;  Q9S4Y8, SELU_SALEN;  B5QUA2, SELU_SALEP;  
B5R637, SELU_SALG2;  B4T9K6, SELU_SALHS;  B4SXL9, SELU_SALNS;  
Q5PCH1, SELU_SALPA;  A9MW55, SELU_SALPB;  C0PVG5, SELU_SALPC;  
B5BD19, SELU_SALPK;  B4TMJ2, SELU_SALSV;  Q8Z8R4, SELU_SALTI;  
Q8ZR88, SELU_SALTY;  A8GFD0, SELU_SERP5;  A1S1Z4, SELU_SHEAM;  
B8EBN0, SELU_SHEB2;  A3DA85, SELU_SHEB5;  A6WHQ4, SELU_SHEB8;  
A9KW78, SELU_SHEB9;  Q12SQ2, SELU_SHEDO;  Q089T3, SELU_SHEFN;  
B0TMW0, SELU_SHEHH;  A3Q958, SELU_SHELP;  Q8EKA0, SELU_SHEON;  
A8GYV2, SELU_SHEPA;  A4YBC0, SELU_SHEPC;  B8CH52, SELU_SHEPW;  
A0KRK0, SELU_SHESA;  A8G1H1, SELU_SHESH;  Q0HNW2, SELU_SHESM;  
Q0I0D0, SELU_SHESR;  A1RP95, SELU_SHESW;  B1KN07, SELU_SHEWM;  
B2TTA2, SELU_SHIB3;  Q324Z4, SELU_SHIBS;  Q32J96, SELU_SHIDS;  
Q0T790, SELU_SHIF8;  Q83SD5, SELU_SHIFL;  Q3Z4Q0, SELU_SHISS;  
Q30RE2, SELU_SULDN;  A6QBB6, SELU_SULNB;  A1WIC3, SELU_VEREI;  

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