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ENZYME

ENZYME entry: EC 2.9.1.3

PURL: https://purl.expasy.org/enzyme/EC/2.9.1.3
Accepted Name
tRNA 2-selenouridine synthase
Reaction catalysed
5-methylaminomethyl-2-thiouridine(34) in tRNA + selenophosphate + (2E)-geranyl diphosphate + H2O + H(+) = 5-methylaminomethyl-2-selenouridine(34) in tRNA + (2E)-thiogeraniol + phosphate + diphosphate
Comment(s)
  • This bacterial enzyme converts 5-methylaminomethyl-2-uridine and 5-carboxymethylaminomethyl-2-uridine to the respective selenouridine forms in a two-step process that involves geranylation and subsequent phosphoselenation of the resulting geranylated intermediates.
  • The resultant seleno-phosphorylated uridine intermediates further react with a water molecule to release a phosphate anion and 2-selenouridine tRNA.
  • The enzyme contains a rhodanese domain.
Cross-references
BRENDA2.9.1.3
EC2PDB2.9.1.3
ExplorEnz2.9.1.3
KEGG Ligand Database for Enzyme Nomenclature2.9.1.3
IUBMB Enzyme Nomenclature2.9.1.3
MEDLINEFind literature relating to 2.9.1.3
MetaCyc2.9.1.3
Rhea expert-curated reactions2.9.1.3
UniProtKB/Swiss-Prot
A0KKE6, SELU_AERHHA4SMM2, SELU_AERS4Q0VNT0, SELU_ALCBS
C1DNN5, SELU_AZOVDQ6MK43, SELU_BDEBAQ7WE96, SELU_BORBR
A9I3Z9, SELU_BORPDQ1R084, SELU_CHRI1Q488J6, SELU_COLP3
A7MJZ3, SELU_CROS8Q0KEU1, SELU_CUPNHQ476K0, SELU_CUPPJ
B2AGP0, SELU_CUPTRA7ZIR0, SELU_ECO24B7UKI1, SELU_ECO27
B7ME26, SELU_ECO45B7L7D0, SELU_ECO55Q8XCZ2, SELU_ECO57
B5YPM0, SELU_ECO5EB7MQL5, SELU_ECO81B7M4K7, SELU_ECO8A
C4ZUV3, SELU_ECOBWB1XFT8, SELU_ECODHA7ZXF7, SELU_ECOHS
A1A8G9, SELU_ECOK1Q0TKD8, SELU_ECOL5Q8FK67, SELU_ECOL6
B1IZ97, SELU_ECOLCP33667, SELU_ECOLIB7N958, SELU_ECOLU
B6I0F4, SELU_ECOSEB1LKC2, SELU_ECOSMQ1RF31, SELU_ECOUT
A4XV44, SELU_ECTM1B7LJH5, SELU_ESCF3Q2SQB9, SELU_HAHCH
Q31GV5, SELU_HYDCUA1U6R9, SELU_MARN8Q0AFI5, SELU_NITEC
Q82WE9, SELU_NITEUQ6LP06, SELU_PHOPRB4F2U3, SELU_PROMH
Q48NL9, SELU_PSE14B7UV78, SELU_PSEA8Q02KC8, SELU_PSEAB
Q9I382, SELU_PSEAEQ1IEL0, SELU_PSEE4Q4KEE7, SELU_PSEF5
A5VYQ1, SELU_PSEP1A6V7E9, SELU_PSEP7Q3K9R2, SELU_PSEPF
B0KPF4, SELU_PSEPGQ88PM7, SELU_PSEPKB1JDU1, SELU_PSEPW
Q889F6, SELU_PSESMQ4ZYK5, SELU_PSEU2A1SRN6, SELU_PSYIN
B5EYB4, SELU_SALA4A9MLB3, SELU_SALARQ57S51, SELU_SALCH
B5FLM4, SELU_SALDCQ9S4Y8, SELU_SALENB5QUA2, SELU_SALEP
B5R637, SELU_SALG2B4T9K6, SELU_SALHSB4SXL9, SELU_SALNS
Q5PCH1, SELU_SALPAA9MW55, SELU_SALPBC0PVG5, SELU_SALPC
B5BD19, SELU_SALPKB4TMJ2, SELU_SALSVQ8Z8R4, SELU_SALTI
Q8ZR88, SELU_SALTYA8GFD0, SELU_SERP5A1S1Z4, SELU_SHEAM
B8EBN0, SELU_SHEB2A3DA85, SELU_SHEB5A6WHQ4, SELU_SHEB8
A9KW78, SELU_SHEB9Q12SQ2, SELU_SHEDOQ089T3, SELU_SHEFN
B0TMW0, SELU_SHEHHA3Q958, SELU_SHELPQ8EKA0, SELU_SHEON
A8GYV2, SELU_SHEPAA4YBC0, SELU_SHEPCB8CH52, SELU_SHEPW
A0KRK0, SELU_SHESAA8G1H1, SELU_SHESHQ0HNW2, SELU_SHESM
Q0I0D0, SELU_SHESRA1RP95, SELU_SHESWB1KN07, SELU_SHEWM
B2TTA2, SELU_SHIB3Q324Z4, SELU_SHIBSQ32J96, SELU_SHIDS
Q0T790, SELU_SHIF8Q83SD5, SELU_SHIFLQ3Z4Q0, SELU_SHISS
Q30RE2, SELU_SULDNA6QBB6, SELU_SULNBA1WIC3, SELU_VEREI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.9.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.9.-.-
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