ENZYME entry: EC 3.1.1.103
Accepted Name |
teichoic acid D-alanine hydrolase.
|
Reaction catalysed |
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H2O <=> [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine |
Comment(s) |
- The enzyme, characterized from the bacterium Staphylococcus aureus,
removes D-alanine groups from the teichoic acid produced by this
organism, thus modulating the electrical charge of the bacterial
surface.
- The activity greatly increases methicillin resistance in MRSA
strains.
|
Cross-references |
BRENDA | 3.1.1.103 |
EC2PDB | 3.1.1.103 |
ExplorEnz | 3.1.1.103 |
PRIAM enzyme-specific profiles | 3.1.1.103 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.1.103 |
IUBMB Enzyme Nomenclature | 3.1.1.103 |
IntEnz | 3.1.1.103 |
MEDLINE | Find literature relating to 3.1.1.103 |
MetaCyc | 3.1.1.103 |
Rhea expert-curated reactions | 3.1.1.103 |
UniProtKB/Swiss-Prot |
|
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