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ENZYME

ENZYME entry: EC 3.1.1.103

Accepted Name
teichoic acid D-alanine hydrolase
Reaction catalysed
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H2O = [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine
Comment(s)
  • The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface.
  • The activity greatly increases methicillin resistance in MRSA strains.
Cross-references
BRENDA3.1.1.103
EC2PDB3.1.1.103
ExplorEnz3.1.1.103
PRIAM enzyme-specific profiles3.1.1.103
KEGG Ligand Database for Enzyme Nomenclature3.1.1.103
IUBMB Enzyme Nomenclature3.1.1.103
IntEnz3.1.1.103
MEDLINEFind literature relating to 3.1.1.103
MetaCyc3.1.1.103
Rhea expert-curated reactions3.1.1.103
UniProtKB/Swiss-Prot
Q2FZK3, FMTA_STAA8Q5HH27, FMTA_STAACQ7A2T0, FMTA_STAAM
Q7A6A2, FMTA_STAANQ6GI27, FMTA_STAARQ6GAF6, FMTA_STAAS
O50608, FMTA_STAAUQ7A185, FMTA_STAAW

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