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ENZYME entry: EC 3.1.1.103

Accepted Name
Teichoic acid D-alanine hydrolase.
Reaction catalysed
((4-D-Ala)-(2-GlcNAc)-Rib-ol-P)(n)-(Gro-P)(m)-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H(2)O <=> ((2-GlcNAc)-Rib-ol-P)(n)-(Gro-P)(m)-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine
Comment(s)
  • The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface.
  • The activity greatly increases methicillin resistance in MRSA strains.
Cross-references
BRENDA3.1.1.103
EC2PDB3.1.1.103
ExplorEnz3.1.1.103
PRIAM enzyme-specific profiles3.1.1.103
KEGG Ligand Database for Enzyme Nomenclature3.1.1.103
IUBMB Enzyme Nomenclature3.1.1.103
IntEnz3.1.1.103
MEDLINEFind literature relating to 3.1.1.103
MetaCyc3.1.1.103
Rhea expert-curated reactions3.1.1.103
UniProtKB/Swiss-Prot
Q2FZK3, FMTA_STAA8;  Q5HH27, FMTA_STAAC;  Q7A2T0, FMTA_STAAM;  
Q7A6A2, FMTA_STAAN;  Q6GI27, FMTA_STAAR;  Q6GAF6, FMTA_STAAS;  
O50608, FMTA_STAAU;  Q7A185, FMTA_STAAW;  

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