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ENZYME entry: EC 3.1.1.111

Accepted Name
phosphatidylserine sn-1 acylhydrolase.
Alternative Name(s)
phosphatidylserine-specific phospholipase A1.
Reaction catalysed
  • a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)
  • a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-L-serine
Comment(s)
The enzyme, which has described from mammals, is specific for phosphatidylserine and 2-lysophosphatidylserine, and does not act on phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid or phosphatidylinositol.
Cross-references
BRENDA3.1.1.111
EC2PDB3.1.1.111
ExplorEnz3.1.1.111
PRIAM enzyme-specific profiles3.1.1.111
KEGG Ligand Database for Enzyme Nomenclature3.1.1.111
IUBMB Enzyme Nomenclature3.1.1.111
IntEnz3.1.1.111
MEDLINEFind literature relating to 3.1.1.111
MetaCyc3.1.1.111
Rhea expert-curated reactions3.1.1.111
UniProtKB/Swiss-Prot
Q5E9H0, PLA1A_BOVIN;  Q53H76, PLA1A_HUMAN;  Q8VI78, PLA1A_MOUSE;  
Q5RBQ5, PLA1A_PONAB;  P97535, PLA1A_RAT;  G5EEM9, PLA1_CAEEL;  

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