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ENZYME entry: EC 3.1.1.25

Accepted Name
1,4-lactonase.
Alternative Name(s)
Gamma-lactonase.
Reaction catalysed
A 1,4-lactone + H(2)O <=> a 4-hydroxyacid
Cofactor(s)
Ca(2+).
Comment(s)
  • Specific for 1,4-lactones with 4-8 carbon atoms.
  • Does not hydrolyze simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4- butyrolactone.
Cross-references
BRENDA3.1.1.25
EC2PDB3.1.1.25
ExplorEnz3.1.1.25
PRIAM enzyme-specific profiles3.1.1.25
KEGG Ligand Database for Enzyme Nomenclature3.1.1.25
IUBMB Enzyme Nomenclature3.1.1.25
IntEnz3.1.1.25
MEDLINEFind literature relating to 3.1.1.25
MetaCyc3.1.1.25
Rhea expert-curated reactions3.1.1.25
UniProtKB/Swiss-Prot
A5IZ80, PFLAC_MYCAP;  Q4A724, PFLAC_MYCS5;  

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