ID 3.1.1.3 DE triacylglycerol lipase. AN lipase. AN tributyrase. AN triglyceride lipase. CA a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+). CC -!- The enzyme is found in diverse organisms including animals, plants, CC fungi, and bacteria. CC -!- It hydrolyzes triglycerides into diglycerides and subsequently into CC monoglycerides and free fatty acids. CC -!- The enzyme is highly soluble in water and acts at the surface of oil CC droplets. CC -!- Access to the active site is controlled by the opening of a lid, CC which, when closed, hides the hydrophobic surface that surrounds the CC active site. CC -!- The lid opens when the enzyme contacts an oil-water interface CC (interfacial activation). CC -!- The pancreatic enzyme requires a protein cofactor, namely colipase, CC to counteract the inhibitory effects of bile salts. DR Q0P5B7, AAAD_BOVIN ; P22760, AAAD_HUMAN ; Q99PG0, AAAD_MOUSE ; DR Q7M370, AAAD_RABIT ; Q9QZH8, AAAD_RAT ; Q0V1P1, AT151_PHANO; DR A6REI4, ATG15_AJECN; A1C6D6, ATG15_ASPCL; Q4X180, ATG15_ASPFU; DR A2QGD9, ATG15_ASPNC; Q0CXU6, ATG15_ASPTN; Q5A4N0, ATG15_CANAL; DR Q6FPI6, ATG15_CANGA; Q2H6M8, ATG15_CHAGB; Q1DZE0, ATG15_COCIM; DR P0CO61, ATG15_CRYNB; P0CO60, ATG15_CRYNJ; Q6BLM0, ATG15_DEBHA; DR Q5B0L1, ATG15_EMENI; Q75EN3, ATG15_EREGS; I1RFN8, ATG15_GIBZE; DR Q6CU02, ATG15_KLULA; A5E567, ATG15_LODEL; A1DH10, ATG15_NEOFI; DR Q7RYY1, ATG15_NEUCR; O13444, ATG15_PASFU; A7KAM5, ATG15_PENRW; DR A7KAJ9, ATG15_PICAN; A5DC90, ATG15_PICGU; A3LV34, ATG15_PICST; DR O13934, ATG15_SCHPO; Q4PHZ2, ATG15_USTMA; A7TG13, ATG15_VANPO; DR Q6C2N7, ATG15_YARLI; A6ZTP2, ATG15_YEAS7; P25641, ATG15_YEAST; DR Q09851, AYR1_SCHPO ; P40471, AYR1_YEAST ; P30122, CEL_BOVIN ; DR P19835, CEL_HUMAN ; Q64285, CEL_MOUSE ; P07882, CEL_RAT ; DR Q8NCG7, DGLB_HUMAN ; Q91WC9, DGLB_MOUSE ; P0C1S9, DGLB_RAT ; DR P37957, ESTA_BACSU ; Q79F14, ESTB_BACSU ; P38139, LDH1_YEAST ; DR P47145, LIH1_YEAST ; Q9P4E5, LIP10_CANAL; Q71DJ5, LIP1_ARATH ; DR D4ASH1, LIP1_ARTBC ; O94091, LIP1_CANAL ; P79066, LIP1_DIPFE ; DR P20261, LIP1_DIURU ; P17573, LIP1_GEOCN ; I1RDA9, LIP1_GIBZE ; DR Q2VG90, LIP1_MALFU ; P19833, LIP1_MORS1 ; P40601, LIP1_PHOLU ; DR Q02104, LIP1_PSYIM ; Q2FUU5, LIP1_STAA8 ; Q5HCM7, LIP1_STAAC ; DR P65288, LIP1_STAAM ; P65289, LIP1_STAAN ; Q6GDD3, LIP1_STAAR ; DR Q6G604, LIP1_STAAS ; Q8NUI5, LIP1_STAAW ; Q9S2A5, LIP1_STRCO ; DR Q99156, LIP1_YARLI ; Q67ZU1, LIP2_ARATH ; D4AZ78, LIP2_ARTBC ; DR Q9P8W5, LIP2_CANAL ; P32946, LIP2_DIURU ; P22394, LIP2_GEOCN ; DR E1CJK0, LIP2_MALFU ; A8QCW4, LIP2_MALGO ; P24484, LIP2_MORS1 ; DR Q2G155, LIP2_STAA8 ; Q5HJ48, LIP2_STAAC ; Q99WQ6, LIP2_STAAM ; DR Q7A7P2, LIP2_STAAN ; Q6GJZ6, LIP2_STAAR ; Q6GCF1, LIP2_STAAS ; DR P10335, LIP2_STAAU ; Q8NYC2, LIP2_STAAW ; Q93J06, LIP2_STRCO ; DR D4B1N9, LIP3_ARTBC ; Q9P8W2, LIP3_CANAL ; P32947, LIP3_DIURU ; DR E1CJK1, LIP3_MALFU ; A8QDF0, LIP3_MALGO ; A0A0K0VEZ4, LIP3_MALR7 ; DR A0A8R9YZM7, LIP3_MALRS ; P24640, LIP3_MORS1 ; Q96VC9, LIP3_YARLI ; DR Q9P8W1, LIP4_CANAL ; P32948, LIP4_DIURU ; E1CJK2, LIP4_MALFU ; DR A8PX35, LIP4_MALGO ; Q9P8W0, LIP5_CANAL ; P32949, LIP5_DIURU ; DR D9N4H3, LIP5_MALFU ; A8QCV7, LIP5_MALGO ; A0A3G2S5J6, LIP5_MALR7 ; DR A0A8R9YVA6, LIP5_MALRS ; Q9P4E8, LIP6_CANAL ; D9N4H4, LIP6_MALFU ; DR A8Q9M3, LIP6_MALGO ; Q9P4E7, LIP7_CANAL ; A8QCV4, LIP7_MALGO ; DR Q9P8V9, LIP8_CANAL ; Q9P4E6, LIP9_CANAL ; D4AX63, LIPA_ARTBC ; DR W3VKA4, LIPA_MOEAP ; Q9P451, LIPA_PENCY ; P26504, LIPA_PSEFL ; DR P0CT91, LIPA_SODAL ; P41365, LIPB_PSEA2 ; P41773, LIPB_PSEFL ; DR Q3SZ79, LIPC_BOVIN ; P11150, LIPC_HUMAN ; P27656, LIPC_MOUSE ; DR O46559, LIPC_RABIT ; P07867, LIPC_RAT ; P40600, LIPE_AERHY ; DR J3RZ81, LIPE_CROAD ; Q29458, LIPF_BOVIN ; P80035, LIPF_CANLF ; DR P07098, LIPF_HUMAN ; Q9CPP7, LIPF_MOUSE ; P04634, LIPF_RAT ; DR Q9Y5X9, LIPG_HUMAN ; Q9WVG5, LIPG_MOUSE ; Q8VBX1, LIPG_RAT ; DR Q94252, LIPL4_CAEEL; P50903, LIPP_CAVPO ; P83629, LIPP_FELCA ; DR P29183, LIPP_HORSE ; P16233, LIPP_HUMAN ; O88354, LIPP_ICTTR ; DR Q6P8U6, LIPP_MOUSE ; Q64425, LIPP_MYOCO ; P00591, LIPP_PIG ; DR Q02157, LIPP_RABIT ; P27657, LIPP_RAT ; A5PK46, LIPR2_BOVIN; DR P81139, LIPR2_CAVPO; P54317, LIPR2_HUMAN; P17892, LIPR2_MOUSE; DR Q64424, LIPR2_MYOCO; D7EZN2, LIPR2_PIG ; P54318, LIPR2_RAT ; DR Q17RR3, LIPR3_HUMAN; P29605, LIPT_BURCE ; I6Y2J4, LIPY_MYCTU ; DR Q5U780, LIP_BACSP ; P22088, LIP_BURCE ; P0DUB8, LIP_BURPL ; DR P26876, LIP_PSEAE ; P08658, LIP_PSEFR ; P0DUB9, LIP_PSEPS ; DR P25275, LIP_PSES5 ; P26877, LIP_PSEU0 ; P19515, LIP_RHIMI ; DR P61871, LIP_RHINI ; P61872, LIP_RHIOR ; P0C0R3, LIP_STAEP ; DR Q5HKP6, LIP_STAEQ ; P0C0R4, LIP_STAES ; P04635, LIP_STAHY ; DR Q93MW7, LIP_STRRM ; O59952, LIP_THELA ; P15493, LIP_VIBCH ; DR Q5VKJ7, OBL1_RICCO ; P0DX29, PETH1_AMYMS; O70320, PLB1_CAVPO ; DR Q6P1J6, PLB1_HUMAN ; Q06HQ7, PLB1_MONDO ; Q3TTY0, PLB1_MOUSE ; DR Q05017, PLB1_RABIT ; O54728, PLB1_RAT ; Q2KI18, PLPL2_BOVIN; DR Q11186, PLPL2_CAEEL; Q96AD5, PLPL2_HUMAN; Q8BJ56, PLPL2_MOUSE; DR P0C548, PLPL2_RAT ; Q9NST1, PLPL3_HUMAN; Q91WW7, PLPL3_MOUSE; DR P41247, PLPL4_HUMAN; Q7Z6Z6, PLPL5_HUMAN; Q32LZ8, PLPL5_MOUSE; DR Q9M1I6, SDP1L_ARATH; Q9LZA6, SDP1_ARATH ; P54857, TGL2_YEAST ; DR Q9Y7P3, TGL3_SCHPO ; P40308, TGL3_YEAST ; O14115, TGL4_SCHPO ; DR P36165, TGL4_YEAST ; Q9Y827, TGL5_SCHPO ; Q12043, TGL5_YEAST ; DR Q06522, YP147_YEAST; //