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ENZYME entry: EC 3.1.1.34

Accepted Name
lipoprotein lipase.
Alternative Name(s)
clearing factor lipase.
diacylglycerol lipase.
diglyceride lipase.
Reaction catalysed
a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)
Comment(s)
  • Hydrolyzes triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles (VLDL).
  • Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein.
  • The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride.
  • The hepatic enzyme (LIPC) also hydrolyzes triglycerides and phospholipids present in circulating plasma lipoproteins.
Cross-references
BRENDA3.1.1.34
EC2PDB3.1.1.34
ExplorEnz3.1.1.34
PRIAM enzyme-specific profiles3.1.1.34
KEGG Ligand Database for Enzyme Nomenclature3.1.1.34
IUBMB Enzyme Nomenclature3.1.1.34
IntEnz3.1.1.34
MEDLINEFind literature relating to 3.1.1.34
MetaCyc3.1.1.34
Rhea expert-curated reactions3.1.1.34
UniProtKB/Swiss-Prot
P11151, LIPL_BOVIN;  P11153, LIPL_CAVPO;  P11602, LIPL_CHICK;  
P55031, LIPL_FELCA;  P06858, LIPL_HUMAN;  P11152, LIPL_MOUSE;  
O46647, LIPL_NEOVI;  P49060, LIPL_PAPAN;  P49923, LIPL_PIG;  
Q06000, LIPL_RAT;  Q29524, LIPL_SHEEP;  

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