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ENZYME entry: EC 3.1.1.53

Accepted Name
sialate O-acetylesterase.
Reaction catalysed
  • H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate
  • H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate
Comment(s)
  • Acts on free and glycosidically-bound N-acetyl- or N-glycoloylneuraminic acid.
  • Acts mainly on 4-O- and 9-O-acetyl groups.
  • Also acts on some other O-acetyl esters, both cyclic and acyclic compounds, which are not sialic acids.
Cross-references
BRENDA3.1.1.53
EC2PDB3.1.1.53
ExplorEnz3.1.1.53
PRIAM enzyme-specific profiles3.1.1.53
KEGG Ligand Database for Enzyme Nomenclature3.1.1.53
IUBMB Enzyme Nomenclature3.1.1.53
IntEnz3.1.1.53
MEDLINEFind literature relating to 3.1.1.53
MetaCyc3.1.1.53
Rhea expert-curated reactions3.1.1.53
UniProtKB/Swiss-Prot
P0C0V9, HEMA_BRV1;  P0C0W0, HEMA_BRV2;  P59711, HEMA_CVBEN;  
P33468, HEMA_CVBF;  Q66165, HEMA_CVBG9;  P59710, HEMA_CVBL9;  
Q9QAR6, HEMA_CVBLS;  Q8V437, HEMA_CVBLU;  P31613, HEMA_CVBLY;  
P15776, HEMA_CVBM;  Q9QAQ9, HEMA_CVBOK;  Q9DR81, HEMA_CVBON;  
P59709, HEMA_CVBQ;  Q5MQD1, HEMA_CVHN1;  Q14EB1, HEMA_CVHN2;  
Q0ZME8, HEMA_CVHN5;  P30215, HEMA_CVHOC;  P31615, HEMA_CVMA5;  
O92367, HEMA_CVMDV;  Q83356, HEMA_CVMJH;  P31614, HEMA_CVMS;  
Q8BB26, HEMA_CVP67;  Q8JSP9, HEMA_CVPIA;  O91262, HEMA_CVPV;  
Q9IKD2, HEMA_CVRSD;  Q9Q9G3, HEMA_HUTV;  P68762, HEMA_INCAA;  
P03465, HEMA_INCCA;  P07973, HEMA_INCEN;  P07971, HEMA_INCGL;  
P17003, HEMA_INCHY;  P07975, HEMA_INCJH;  P17004, HEMA_INCKY;  
P07970, HEMA_INCMI;  P17005, HEMA_INCNA;  Q67387, HEMA_INCNB;  
P07968, HEMA_INCP1;  P07967, HEMA_INCP2;  P07966, HEMA_INCP3;  
P07974, HEMA_INCTA;  P68761, HEMA_INCYA;  P87691, HEMA_INCYB;  
Q8V3U0, HEMA_ISAV8;  Q70KP1, HEMA_PTV10;  Q9HAT2, SIAE_HUMAN;  
P70665, SIAE_MOUSE;  Q5RFU0, SIAE_PONAB;  P82450, SIAE_RAT;  

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