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ENZYME entry: EC 3.1.1.75

Accepted Name
poly(3-hydroxybutyrate) depolymerase.
Alternative Name(s)
PHB depolymerase.
poly(3HB) depolymerase.
poly(HA) depolymerase.
poly(HASCL) depolymerase.
poly[(R)-hydroxyalkanoic acid] depolymerase.
Reaction catalysed
  • [(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)
  • [(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)
  • [(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)
  • [(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)
  • [(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)
Comment(s)
  • Reaction also occurs with esters of other short-chain-length (C1-C5) hydroxyalkanoic acids (HA).
  • There are two types of polymers: native (intracellular) granules are amorphous and have an intact surface layer; denatured (extracellular) granules either have no surface layer or a damaged surface layer and are partially crystalline.
Cross-references
BRENDA3.1.1.75
EC2PDB3.1.1.75
ExplorEnz3.1.1.75
PRIAM enzyme-specific profiles3.1.1.75
KEGG Ligand Database for Enzyme Nomenclature3.1.1.75
IUBMB Enzyme Nomenclature3.1.1.75
IntEnz3.1.1.75
MEDLINEFind literature relating to 3.1.1.75
MetaCyc3.1.1.75
Rhea expert-curated reactions3.1.1.75
UniProtKB/Swiss-Prot
P12625, PHB_RALPI

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