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ENZYME entry: EC 3.1.1.76

Accepted Name
poly(3-hydroxyoctanoate) depolymerase.
Alternative Name(s)
PHA depolymerase.
PHO depolymerase.
poly(3HO) depolymerase.
poly(HA) depolymerase.
poly(HAMCL) depolymerase.
poly[(R)-3-hydroxyoctanoate] hydrolase.
poly[(R)-hydroxyalkanoic acid] depolymerase.
Reaction catalysed
Hydrolyzes the polyester poly{oxycarbonyl[(R)-2-pentylethylene]} to oligomers
Comment(s)
  • The main product after prolonged incubation is the dimer.
  • Besides hydrolyzing polymers of 3-hydroxyoctanoic acid, the enzyme also hydrolyzes other polymers derived from medium-chain-length (C6-C12) hydroxyalkanoic acids and copolymers of mixtures of these.
  • It also hydrolyzes p-nitrophenyl esters of fatty acids.
  • Polymers of short-chain-length hydroxyalkanoic acids such as poly[(R)-3-hydroxybutanoic acid] and poly[(R)-3-hydroxypentanoic acid] are not hydrolyzed.
Cross-references
BRENDA3.1.1.76
EC2PDB3.1.1.76
ExplorEnz3.1.1.76
PRIAM enzyme-specific profiles3.1.1.76
KEGG Ligand Database for Enzyme Nomenclature3.1.1.76
IUBMB Enzyme Nomenclature3.1.1.76
IntEnz3.1.1.76
MEDLINEFind literature relating to 3.1.1.76
MetaCyc3.1.1.76
Rhea expert-curated reactions3.1.1.76
UniProtKB/Swiss-Prot
Q51718, PHAZ_PSEFL

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