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ENZYME entry: EC 3.1.1.76

Accepted Name
Poly(3-hydroxyoctanoate) depolymerase.
Alternative Name(s)
PHA depolymerase.
PHO depolymerase.
Poly((R)-3-hydroxyoctanoate) hydrolase.
Poly((R)-hydroxyalkanoic acid) depolymerase.
Poly(3HO) depolymerase.
Poly(HA(MCL)) depolymerase.
Poly(HA) depolymerase.
Reaction catalysed
Hydrolyzes the polyester poly(oxycarbonyl((R)-2-pentylethylene)) to oligomers
Comment(s)
  • The main product after prolonged incubation is the dimer.
  • Besides hydrolyzing polymers of 3-hydroxyoctanoic acid, the enzyme also hydrolyzes other polymers derived from medium-chain-length (C(6)-C(12)) hydroxyalkanoic acids and copolymers of mixtures of these.
  • It also hydrolyzes p-nitrophenyl esters of fatty acids.
  • Polymers of short-chain-length hydroxyalkanoic acids such as poly((R)-3-hydroxybutanoic acid) and poly((R)-3-hydroxypentanoic acid) are not hydrolyzed.
Cross-references
BRENDA3.1.1.76
EC2PDB3.1.1.76
ExplorEnz3.1.1.76
PRIAM enzyme-specific profiles3.1.1.76
KEGG Ligand Database for Enzyme Nomenclature3.1.1.76
IUBMB Enzyme Nomenclature3.1.1.76
IntEnz3.1.1.76
MEDLINEFind literature relating to 3.1.1.76
MetaCyc3.1.1.76
Rhea expert-curated reactions3.1.1.76
UniProtKB/Swiss-Prot
Q51718, PHAZ_PSEFL

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