ID   3.1.1.77
DE   acyloxyacyl hydrolase.
CA   a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl
CA   derivative of bacterial toxin + a fatty acid + H(+).
CC   -!- The substrate is lipid A on the reducing end of the toxic
CC       lipopolysaccharide (LPS) of Salmonella typhimurium and related
CC       organisms.
CC   -!- It consists of diglucosamine, beta-D-GlcN-(1->6)-D-GlcN, attached by
CC       glycosylation on O-6 of its non-reducing residue, phosphorylated on
CC       O-4 of this residue and on O-1 of its potentially reducing residue.
CC   -!- Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3.
CC   -!- The enzyme from human leukocytes detoxifies the lipid by hydrolyzing
CC       the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the
CC       disaccharide (LPS).
CC   -!- It also possesses a wide range of phospholipase and acyltransferase
CC       activities (e.g. EC 3.1.1.4, EC 3.1.1.5, EC 3.1.1.32 and
CC       EC 3.1.1.52), hydrolyzing diacylglycerol and phosphatidyl compounds,
CC       but not triacylglycerols.
CC   -!- It has a preference for saturated C12-C16 acyl groups.
DR   P28039, AOAH_HUMAN ;  O35298, AOAH_MOUSE ;  O18823, AOAH_RABIT ;
DR   Q7WD07, PAGL_BORBR ;  Q9HVD1, PAGL_PSEAE ;
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