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ENZYME

ENZYME entry: EC 3.1.1.79

PURL: https://purl.expasy.org/enzyme/EC/3.1.1.79
Accepted Name
hormone-sensitive lipase
Alternative Name(s)
HSL
Reaction catalysed
  • a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
  • a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
Comment(s)
  • This enzyme is a serine hydrolase.
  • Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity.
  • It hydrolyzes all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) as well as cholesteryl esters, steroid fatty acid esters, retinyl esters and p-nitrophenyl esters.
  • It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond.
  • The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length.
  • The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
Cross-references
BRENDA3.1.1.79
EC2PDB3.1.1.79
ExplorEnz3.1.1.79
KEGG Ligand Database for Enzyme Nomenclature3.1.1.79
IUBMB Enzyme Nomenclature3.1.1.79
MEDLINEFind literature relating to 3.1.1.79
MetaCyc3.1.1.79
Rhea expert-curated reactions3.1.1.79
UniProtKB/Swiss-Prot
Q802V6, ABH2A_DANREQ05AK6, ABH2B_DANREQ5EA42, ABHD2_BOVIN
P08910, ABHD2_HUMANQ4R2Y9, ABHD2_MACFAQ9QXM0, ABHD2_MOUSE
P16386, LIPS_BOVINQ05469, LIPS_HUMANQ9R101, LIPS_ICTTR
P54310, LIPS_MOUSEQ68J42, LIPS_PIGP15304, LIPS_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-