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ENZYME

ENZYME entry: EC 3.1.1.80

PURL: https://purl.expasy.org/enzyme/EC/3.1.1.80
Accepted Name
acetylajmaline esterase
Alternative Name(s)
2beta(R)-17-O-acetylajmalan:acetylesterase
AAE
acetylajmalan esterase
Reaction catalysed
  • 17-O-acetylajmaline + H2O = ajmaline + acetate + H(+)
  • 17-O-acetylnorajmaline + H2O = norajmaline + acetate + H(+)
Comment(s)
  • Responsible for the last stages in the biosynthesis of the indole alkaloid ajmaline.
  • Highly specific for the substrates 17-O-acetylajmaline and 17-O- acetylnorajmaline as the structurally related acetylated alkaloids vinorine, vomilenine, 1,2-dihydrovomilenine and 1,2- dihydroraucaffricine cannot act as substrates.
Cross-references
Rhea expert-curated reactions3.1.1.80
ExplorEnz3.1.1.80
IUBMB Enzyme Nomenclature3.1.1.80
UniProtKB/Swiss-Prot
P0DXJ4, AAE1_RAUSEP0DXJ5, AAE2_RAUSEQ3MKY2, AAE_RAUSE
P86830, AAE_RAUVE
BRENDA3.1.1.80
MetaCyc3.1.1.80
KEGG Ligand Database for Enzyme Nomenclature3.1.1.80
EC2PDB3.1.1.80
MEDLINEFind literature relating to 3.1.1.80

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