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ENZYME

ENZYME entry: EC 3.1.1.81

Accepted Name
quorum-quenching N-acyl-homoserine lactonase
Alternative Name(s)
acyl homoserine degrading enzyme
acyl-homoserine-lactone acylase
AHLase
AHL-degrading enzyme
AHL-inactivating enzyme
AHL lactonase
N-acyl homoserine lactonase
N-acyl homoserine lactone hydrolase
N-acyl-homoserine lactone lactonase
N-acyl-L-homoserine lactone hydrolase
quorum-quenching lactonase
quorum-quenching N-acyl homoserine lactone hydrolase
Reaction catalysed
an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)
Comment(s)
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
Cross-references
BRENDA3.1.1.81
EC2PDB3.1.1.81
ExplorEnz3.1.1.81
PRIAM enzyme-specific profiles3.1.1.81
KEGG Ligand Database for Enzyme Nomenclature3.1.1.81
IUBMB Enzyme Nomenclature3.1.1.81
IntEnz3.1.1.81
MEDLINEFind literature relating to 3.1.1.81
MetaCyc3.1.1.81
Rhea expert-curated reactions3.1.1.81
UniProtKB/Swiss-Prot
P0CJ63, AHLLA_BACTKA9CKY2, AHLLB_AGRFCB9JPK6, AHLLB_AGRRK
Q7D3U0, AHLLM_AGRFCA8IQD2, AHLLM_AZOC5Q1M813, AHLLM_RHIL3
Q8VPD5, AHLLM_RHIRDQ7X3T2, AHLL_ARTSPQ08GP4, AHLL_BACCE
Q9L8R8, AHLL_BACSPQ7B8C3, AHLL_BACT3Q7B8C5, AHLL_BACTA
A3FJ64, AHLL_BACTUC6L862, AHLL_MICTSP27169, PON1_HUMAN
P52430, PON1_MOUSEP27170, PON1_RABITP55159, PON1_RAT
Q58DS7, PON2_BOVINP54832, PON2_CANLFQ15165, PON2_HUMAN
Q62086, PON2_MOUSEQ6AXM8, PON2_RATQ15166, PON3_HUMAN
Q62087, PON3_MOUSEQ9BGN0, PON3_RABITQ68FP2, PON3_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
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