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ENZYME

ENZYME entry: EC 3.1.1.85

Accepted Name
pimeloyl-[acyl-carrier protein] methyl ester esterase
Reaction catalysed
6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol
Comment(s)
  • Involved in biotin biosynthesis in Gram-negative bacteria.
  • The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains.
  • Even though the enzyme can interact with coenzyme A thioesters, the in vivo role of the enzyme is to hydrolyze the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalyzed by the fatty acid elongation enzymes.
Cross-references
BRENDA3.1.1.85
EC2PDB3.1.1.85
ExplorEnz3.1.1.85
PRIAM enzyme-specific profiles3.1.1.85
KEGG Ligand Database for Enzyme Nomenclature3.1.1.85
IUBMB Enzyme Nomenclature3.1.1.85
IntEnz3.1.1.85
MEDLINEFind literature relating to 3.1.1.85
MetaCyc3.1.1.85
Rhea expert-curated reactions3.1.1.85
UniProtKB/Swiss-Prot
A0KF11, BIOH_AERHHA4ST17, BIOH_AERS4Q5E8N3, BIOH_ALIF1
B5FFE9, BIOH_ALIFMB6EPQ0, BIOH_ALISLQ5NZF6, BIOH_AROAE
Q89A54, BIOH_BUCBPQ7NPW5, BIOH_CHRVOA8AQW5, BIOH_CITK8
A7MGD2, BIOH_CROS8A7ZSU1, BIOH_ECO24B7UKB7, BIOH_ECO27
B7MDN8, BIOH_ECO45B7L4T9, BIOH_ECO55Q8X716, BIOH_ECO57
B5YTW3, BIOH_ECO5EB7NMH7, BIOH_ECO7IB7N145, BIOH_ECO81
B7M1W8, BIOH_ECO8AC4ZUR7, BIOH_ECOBWB1X758, BIOH_ECODH
A8A5M0, BIOH_ECOHSA1AGT6, BIOH_ECOK1Q0TC55, BIOH_ECOL5
Q8FCT4, BIOH_ECOL6B1IP53, BIOH_ECOLCP13001, BIOH_ECOLI
B7NE17, BIOH_ECOLUB6I2X6, BIOH_ECOSEB1LHL2, BIOH_ECOSM
Q1R5M2, BIOH_ECOUTC5BGT3, BIOH_EDWI9B7LSB5, BIOH_ESCF3
C4K407, BIOH_HAMD5Q5QZC0, BIOH_IDILOB5XTS4, BIOH_KLEP3
A6TF35, BIOH_KLEP7Q5X590, BIOH_LEGPAA5IBW4, BIOH_LEGPC
Q5ZVG6, BIOH_LEGPHQ5WW99, BIOH_LEGPLQ609V0, BIOH_METCA
Q5F641, BIOH_NEIG1Q9JSN0, BIOH_NEIMAQ9K197, BIOH_NEIMB
A1KRU9, BIOH_NEIMFE6MWF8, BIOH_NEIMHQ82SL8, BIOH_NITEU
Q2Y9Y7, BIOH_NITMUQ6CZL9, BIOH_PECASC6DGH6, BIOH_PECCP
Q7N9V7, BIOH_PHOLLQ6LVQ7, BIOH_PHOPRB4EZM6, BIOH_PROMH
Q15N09, BIOH_PSEA6B5F8M6, BIOH_SALA4A9MMB5, BIOH_SALAR
Q57IW5, BIOH_SALCHB5FJT1, BIOH_SALDCB5R369, BIOH_SALEP
B5R7K5, BIOH_SALG2B4TKT6, BIOH_SALHSB4SVL3, BIOH_SALNS
Q5PLY8, BIOH_SALPAC0Q0I5, BIOH_SALPCB5BHG7, BIOH_SALPK
Q8Z221, BIOH_SALTIQ8ZLI9, BIOH_SALTYQ8GHL1, BIOH_SERMA
A8GKT5, BIOH_SERP5Q8E8N6, BIOH_SHEONQ0HPU6, BIOH_SHESR
B1KM44, BIOH_SHEWMB2U3M2, BIOH_SHIB3Q31VM0, BIOH_SHIBS
Q32AM6, BIOH_SHIDSQ83PW0, BIOH_SHIFLQ3YWL3, BIOH_SHISS
Q2NQH6, BIOH_SODGMB4SM83, BIOH_STRM5B2FLM6, BIOH_STRMK
C4LA13, BIOH_TOLATB7VHH1, BIOH_VIBA3A7MST3, BIOH_VIBC1
Q9KNL4, BIOH_VIBCHQ87TC2, BIOH_VIBPAQ8DDU4, BIOH_VIBVU
Q7MPY0, BIOH_VIBVYQ8D1X1, BIOH_WIGBRQ8PQE0, BIOH_XANAC
Q4UZP1, BIOH_XANC8B0RMQ9, BIOH_XANCBQ8PDF3, BIOH_XANCP
Q2P907, BIOH_XANOMQ5H6D1, BIOH_XANORB2I9H6, BIOH_XYLF2
Q9PDM3, BIOH_XYLFAB0U6I9, BIOH_XYLFMQ87DT3, BIOH_XYLFT
A1JSF8, BIOH_YERE8A7FNV8, BIOH_YERP3B2K5V7, BIOH_YERPB
Q74Y45, BIOH_YERPEA9R4D0, BIOH_YERPGQ664J8, BIOH_YERPS
B1JHZ5, BIOH_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
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