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ENZYME

ENZYME entry: EC 3.1.1.88

PURL: https://purl.expasy.org/enzyme/EC/3.1.1.88
Accepted Name
pyrethroid hydrolase
Alternative Name(s)
permethrinase
pyrethroid-cleaving enzyme
pyrethroid-hydrolyzing carboxylesterase
pyrethroid-hydrolyzing esterase
pyrethroid-selective esterase
Reaction catalysed
(-)-trans-permethrin + H2O = (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H(+)
Comment(s)
  • The enzyme is involved in degradation of pyrethroid pesticides.
  • The enzymes from Sphingobium sp., Klebsiella sp. and Aspergillus niger hydrolyze cis-permethrin at approximately equal rate to trans- permethrin.
  • The enzyme from mouse hydrolyzes trans-permethrin at a rate about 22-fold higher than cis-permethrin.
Cross-references
BRENDA3.1.1.88
EC2PDB3.1.1.88
ExplorEnz3.1.1.88
KEGG Ligand Database for Enzyme Nomenclature3.1.1.88
IUBMB Enzyme Nomenclature3.1.1.88
MEDLINEFind literature relating to 3.1.1.88
MetaCyc3.1.1.88
Rhea expert-curated reactions3.1.1.88
UniProtKB/Swiss-Prot
Q8QZR3, EST2A_MOUSEQ8K3R0, EST2A_RATQ8BK48, EST2E_MOUSE
G3V7J5, EST2E_RATQ52NW7, PYRHY_KLESPC0LA90, PYRHY_SPHWJ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-