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ENZYME entry: EC 3.1.1.88

Accepted Name
pyrethroid hydrolase.
Alternative Name(s)
permethrinase.
pyrethroid-cleaving enzyme.
pyrethroid-hydrolyzing carboxylesterase.
pyrethroid-hydrolyzing esterase.
pyrethroid-selective esterase.
Reaction catalysed
(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)
Comment(s)
  • The enzyme is involved in degradation of pyrethroid pesticides.
  • The enzymes from Sphingobium sp., Klebsiella sp. and Aspergillus niger hydrolyze cis-permethrin at approximately equal rate to trans- permethrin.
  • The enzyme from mouse hydrolyzes trans-permethrin at a rate about 22-fold higher than cis-permethrin.
Cross-references
BRENDA3.1.1.88
EC2PDB3.1.1.88
ExplorEnz3.1.1.88
PRIAM enzyme-specific profiles3.1.1.88
KEGG Ligand Database for Enzyme Nomenclature3.1.1.88
IUBMB Enzyme Nomenclature3.1.1.88
IntEnz3.1.1.88
MEDLINEFind literature relating to 3.1.1.88
MetaCyc3.1.1.88
Rhea expert-curated reactions3.1.1.88
UniProtKB/Swiss-Prot
Q8QZR3, EST2A_MOUSE;  Q8K3R0, EST2A_RAT;  Q8BK48, EST2E_MOUSE;  
G3V7J5, EST2E_RAT;  Q52NW7, PYRHY_KLESP;  C0LA90, PYRHY_SPHWJ;  

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